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Series GSE4725 Query DataSets for GSE4725
Status Public on Dec 11, 2007
Title Hypoxia
Organism Homo sapiens
Experiment type Expression profiling by array
Summary Systemic arterial smooth muscle cells are exposed to a broad range of oxygen concentrations under physiological conditions. Hypoxia can modulate the proliferative response of smooth muscle cells leading to speculation about its role in vasculogenesis, vascular remodelling and the pathogenesis of arterial disease. The effect of hypoxia has been inconsistent, however, with both enhanced proliferation and growth arrest reported. Nevertheless, these reports support an important effect of hypoxia on smooth muscle cell proliferation and, given its physiological and clinical relevance, this requires clarification. We posited that variation in O2 concentration, within the range that exists in vivo, may have different effects on the proliferation and survival of vascular smooth muscle cells.
Keywords: expression profiles of hypoxia (1% and 3%) in HASMC
Overall design Human aortic smooth muscle cells (HASMC) were propagated to passage 6 in SMGM-2 medium reached 80% confluence, the media was changed and the cells were incubated for a further 16 hrs or 48 hrs under either normoxic or hypoxic conditions (1% and 3%O2 ).
Contributor(s) Arab S, Basuray J, Ward M, Liu P
Citation(s) 18055518
Submission date Apr 26, 2006
Last update date Aug 10, 2018
Contact name Sara Arab
Organization name Toronto General Hospital
Department Cardiology
Lab M. Husain
Street address 610 University Avenue
City Toronto
State/province ONT
ZIP/Postal code M5G 2M9
Country Canada
Platforms (1)
GPL96 [HG-U133A] Affymetrix Human Genome U133A Array
Samples (6)
GSM105362 Control for 1% Oxygen
GSM107839 3% Oxygen 16h
GSM107840 3% Oxygen 48h
BioProject PRJNA95583

Download family Format
SOFT formatted family file(s) SOFTHelp
MINiML formatted family file(s) MINiMLHelp
Series Matrix File(s) TXTHelp

Supplementary file Size Download File type/resource
GSE4725_RAW.tar 20.4 Mb (http)(custom) TAR (of CEL, EXP)
Processed data included within Sample table

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