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Series GSE4698 Query DataSets for GSE4698
Status Public on Sep 27, 2006
Title Molecular characterization of very early relapsed childhood ALL
Organism Homo sapiens
Experiment type Expression profiling by array
Summary Purpose: In childhood acute lymphoblastic leukemia (ALL), approximately 25% of patients suffer from relapse. In recurrent disease, despite intensified therapy, overall cure rates of 40% remain unsatisfactory and survival rates are particularly poor in certain subgroups. The probability of long-term survival after relapse is predicted from well-established prognostic factors, i. e. time and site of relapse, immunophenotype and minimal residual disease. However, the underlying biological determinants of these prognostic factors remain poorly understood.
Results: We show here that patients with very early relapse of ALL are characterized by a distinctive gene expression pattern. We identified a set of 83 genes differentially expressed in very early relapsed ALL compared to late relapsed disease. The vast majority of genes was up-regulated and many were late cell cycle genes with a function in mitosis. In addition, samples from patients with very early relapse showed a significant increase in the percentage of S and G/2M phase cells and this correlated well with the expression level of cell cycle genes.
Conclusions: Very early relapse of ALL is characterized by an increased proliferative capacity of leukemic blasts and up-regulated mitotic genes. The latter suggests that novel drugs, targeting late cell cycle proteins, might be beneficial for these patients that typically face a dismal prognosis.
Keywords: disease state analysis
Overall design We performed gene expression profiling on 60 prospectively collected samples of children with first relapse of acute lymphoblastic leukemia enrolled on the relapse trial ALL-REZ BFM 2002 of the Berlin-Frankfurt-Muenster study group.
Contributor(s) Kirschner-Schwabe R, Lottaz C, Toedling J, Thein P, Karawajew L, Eckert C, von Stackelberg A, Ungethuem U, Kostka D, Kulozik AE, Ludwig W, Henze G, Spang R, Hagemeier C, Seeger K
Citation(s) 16899601
Submission date Apr 21, 2006
Last update date Nov 14, 2018
Contact name Renate Kirschner-Schwabe
Phone +4930450566088
Fax +4930450566946
Organization name Charité - Universitätsmedizin Berlin
Department Pediatric Oncology/Hematology
Lab Molecular Genetics
Street address Augustenburger Platz 1
City Berlin
ZIP/Postal code 12167
Country Germany
Platforms (1)
GPL96 [HG-U133A] Affymetrix Human Genome U133A Array
Samples (60)
BioProject PRJNA96749

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Supplementary file Size Download File type/resource
GSE4698_RAW.tar 202.6 Mb (http)(custom) TAR (of CEL, EXP)

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