GEO Logo
   NCBI > GEO > Accession DisplayHelp Not logged in | LoginHelp
GEO help: Mouse over screen elements for information.
Series GSE46926 Query DataSets for GSE46926
Status Public on Aug 13, 2014
Title Genome-wide analysis of the effects of the novel mithramycin analogue DIG-MSK on human A2780 ovarian carcinoma cells
Organism Homo sapiens
Experiment type Expression profiling by array
Summary The effects of demycarosyl-3D-β-D-digitoxosyl-mithramycin SK (DIG-MSK; EC-8042), a novel analogue of the antitumor antibiotic mithramycin A, on gene transcription were examined in human A2780 ovarian carcinoma cells. DIG-MSK down-regulated a different set of genes depending on the drug concentration. Moreover, several genes were significantly up-regulated. These results are rationalized in terms of DIG-MSK competition with Sp1 transcription factor for binding to consensus C/G-rich tracts encompassed in gene promoters.
Overall design Human A2780 ovarian carcinoma cells were treated with either 8 nM or 80 nM DIG-MSK for 24 h, and RNA was extracted from treated cells as well as from untreated (control) cells.
Contributor(s) Portugal J, Vizcaíno C, Morís F
Citation(s) 25110883
Submission date May 14, 2013
Last update date Nov 27, 2018
Contact name José Portugal
Organization name Instituto de Biologia Molecular de Barcelona-CSIC
Department Molecular Genomics
Street address Parc Cientific de Barcelona, Baldiri Reixac, 10
City Barcelona
ZIP/Postal code E-08028
Country Spain
Platforms (1)
GPL13607 Agilent-028004 SurePrint G3 Human GE 8x60K Microarray (Feature Number version)
Samples (9)
GSM1141253 0nM_rep1
GSM1141254 0nM_rep2
GSM1141255 0nM_rep3
BioProject PRJNA203041

Download family Format
SOFT formatted family file(s) SOFTHelp
MINiML formatted family file(s) MINiMLHelp
Series Matrix File(s) TXTHelp

Supplementary file Size Download File type/resource
GSE46926_RAW.tar 33.0 Mb (http)(custom) TAR (of TXT)
Processed data included within Sample table

| NLM | NIH | GEO Help | Disclaimer | Accessibility |
NCBI Home NCBI Search NCBI SiteMap