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Series GSE46648 Query DataSets for GSE46648
Status Public on Aug 30, 2013
Title Identification of DNA methylation changes in monocytes to osteoclast differentiation
Organism Homo sapiens
Experiment type Methylation profiling by genome tiling array
Summary Conversion of monocytes to osteoclasts is a unique terminal differentiation process within the hematopoietic system involving differentiation and massive cell fusion. Here we focused on DNA methylation changes during osteoclastogenesis. Hypermethylation and hypomethylation changes took place in several thousand genes, including all relevant functional categories in osteoclast differentiation and function.
Overall design Comparison between the DNA methylation levels of CD14+ monocytes and derived osteoclast from 3 female donors. Bisulphite converted DNA from the 6 samples was hybridised to the Illumina Infinium 450k Human Methylation Beadchip
Contributor(s) de la Rica L, García M, Rodríguez-Ubreva J, Islam AB, Urquiza JM, Hernando H, Christensen J, Helin K, Gómez-Vaquero C, Ballestar E
Citation(s) 24028770
Submission date May 06, 2013
Last update date Mar 22, 2019
Contact name Esteban Ballestar
Organization name Josep Carreras Research Institute (IJC)
Lab Epigenetics and Immune Disease
Street address Ctra de Can Ruti, Camí de les Escoles s/n
City Badalona, Barcelona
State/province N/A = Not Applicable
ZIP/Postal code 08916
Country Spain
Platforms (1)
GPL13534 Illumina HumanMethylation450 BeadChip (HumanMethylation450_15017482)
Samples (6)
GSM1133590 CD14_Monocyte_individual1
GSM1133591 CD14_Monocyte_individual2
GSM1133592 CD14_Monocyte_individual3
BioProject PRJNA201402

Download family Format
SOFT formatted family file(s) SOFTHelp
MINiML formatted family file(s) MINiMLHelp
Series Matrix File(s) TXTHelp

Supplementary file Size Download File type/resource
GSE46648_RAW.tar 183.1 Mb (http)(custom) TAR
GSE46648_meth_unmeth_intensities.txt.gz 15.6 Mb (ftp)(http) TXT
Processed data included within Sample table

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