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Series GSE46394 Query DataSets for GSE46394
Status Public on Aug 12, 2014
Title Genome-wide DNA methylation aberrations in human atherosclerosis (450K)
Organism Homo sapiens
Experiment type Methylation profiling by array
Summary Epigenetics may help understanding the molecular mechanisms of atherosclerosis as genetic predisposition explains only part of cardiovascular disease risk. In particular, DNA methylation, a reversible and highly regulative DNA modification could contribute to disease onset and progression as it functions as effector for environmental impacts, including dietary and life-style, similarly to risk factors for cardiovascular diseases. We addressed this issue by performing whole-genome shotgun bisulfite sequencing and high-resolution DNAmethylation array analysis of healthy and diseased donor-matched atherosclerotic DNA methylomes.
Overall design Sequencing of bisulfite converted DNA and array based analysis of atherosclerotic lesions and normal carotid tissue.
Contributor(s) Esteller M, Heyn H
Citation(s) 25091541, 25881171, 35657981
Submission date Apr 25, 2013
Last update date Jun 23, 2022
Contact name Manel Esteller
Organization name IDIBELL
Department PEBC
Lab Cancer Epigenetics
Street address Hospital Duran i Reynals Av. Gran Via s/n km, 2.7
City L'Hospitalet de Llobregat
State/province Barcelona
ZIP/Postal code 08908
Country Spain
Platforms (1)
GPL13534 Illumina HumanMethylation450 BeadChip (HumanMethylation450_15017482)
Samples (49)
GSM1129686 Atherosclerotic lesion 93
GSM1129687 Atherosclerotic lesion 95
GSM1129688 Atherosclerotic lesion 96
This SubSeries is part of SuperSeries:
GSE46401 Genome-wide DNA methylation aberrations in human atherosclerosis
BioProject PRJNA200087

Download family Format
SOFT formatted family file(s) SOFTHelp
MINiML formatted family file(s) MINiMLHelp
Series Matrix File(s) TXTHelp

Supplementary file Size Download File type/resource
GSE46394_RAW.tar 183.1 Mb (http)(custom) TAR
GSE46394_methylated_unmethylated_data.txt.gz 209.4 Mb (ftp)(http) TXT
Processed data included within Sample table

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