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Series GSE45930 Query DataSets for GSE45930
Status Public on Jan 07, 2015
Title TRIM28 silences endogenous retroviruses in neural progenitor cells
Organism Mus musculus
Experiment type Expression profiling by high throughput sequencing
Summary Here we show that in neural progenitor cells (NPCs) TRIM28 silences transcription of two groups of endogenous retroviruses (ERVs): IAP1 and MMERVK10C. Derepression of ERVs in Trim28-deficient NPCs was associated with a loss of H3K9me3 and resulted in transcriptional upregulation and reverse transcription. These findings demonstrate a unique dynamic transcriptional regulation of ERVs in NPCs.
Overall design Analysis of upregulation of ERVs in Trim28-deficient NPCs
Contributor(s) Fasching L, Kapopoulou A, Sachdeva R, Petri R, Jönsson ME, Männe C, Turelli P, Jern P, Cammas F, Trono D, Jakobsson J
Citation(s) 25543143
Submission date Apr 10, 2013
Last update date May 15, 2019
Contact name Adamandia Kapopoulou
Phone 0041216930940
Organization name EPFL
Department Sciences de la Vie
Lab Trono
Street address Station 15
City Lausanne
ZIP/Postal code 1015
Country Switzerland
Platforms (1)
GPL13112 Illumina HiSeq 2000 (Mus musculus)
Samples (6)
GSM1119762 ctrl NPCs RNA-seq 1
GSM1119763 ctrl NPCs RNA-seq 2
GSM1119764 ctrl NPCs RNA-seq 3
BioProject PRJNA196678
SRA SRP020909

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Supplementary file Size Download File type/resource
GSE45930_repbase_ko_vs_wt.txt.gz 8.9 Kb (ftp)(http) TXT
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