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Series GSE45875 Query DataSets for GSE45875
Status Public on Aug 15, 2013
Title Genome-wide survey of YY1 targets in C2C12 cells by High-throughput sequencing
Organism Mus musculus
Experiment type Genome binding/occupancy profiling by high throughput sequencing
Summary By applying ChIP-seq, we generated genome-wide maps of YY1 in skeletal myoblasts and myotubes. We found that YY1 binds to 1820 confident target with a large portion residing in the intergenic regions. In addition, YY1 was found to activate many loci, and there is no significant overlap between YY1 and Ezh2 targets, suggensting a Ezh2-independent manner. Further detailed study revealed that YY1 can regulate some lincRNAs which are fucntional in skeletal myogenesis. In this study, we identified a YY1-Yam-1-miR-715 (TF-lincRNA-miRNA) regulatory curcuit in myogensis.
Overall design Examination of YY1 targets in myoblast versus myotubes
Contributor(s) Wang H, Sun H, Lu L, Sun K, Chen X, Wang L, Zhao Y, Zhou L
Citation(s) 23942234, 26484078
Submission date Apr 08, 2013
Last update date May 15, 2019
Contact name Kun Sun
Organization name Shenzhen Bay Laboratory
Department Cancer Research
Lab Kun Sun
Street address Rm B505, No. 9 Duxue Road, Nanshan District
City Shenzhen
ZIP/Postal code 518107
Country China
Platforms (2)
GPL11002 Illumina Genome Analyzer IIx (Mus musculus)
GPL13112 Illumina HiSeq 2000 (Mus musculus)
Samples (8)
GSM1117981 YY1_MB_SC1703_ChIP-seq
GSM1117982 YY1_MB_AB58066_ChIP-seq
GSM1117983 YY1_MT_ChIP-seq
SRA SRP020624
BioProject PRJNA196689

Download family Format
SOFT formatted family file(s) SOFTHelp
MINiML formatted family file(s) MINiMLHelp
Series Matrix File(s) TXTHelp

Supplementary file Size Download File type/resource
GSE45875_RAW.tar 380.0 Kb (http)(custom) TAR (of BEDGRAPH, TXT)
SRA Run SelectorHelp
Raw data are available in SRA
Processed data provided as supplementary file

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