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Series GSE45875 Query DataSets for GSE45875
Status Public on Aug 15, 2013
Title Genome-wide survey of YY1 targets in C2C12 cells by High-throughput sequencing
Organism Mus musculus
Experiment type Genome binding/occupancy profiling by high throughput sequencing
Summary By applying ChIP-seq, we generated genome-wide maps of YY1 in skeletal myoblasts and myotubes. We found that YY1 binds to 1820 confident target with a large portion residing in the intergenic regions. In addition, YY1 was found to activate many loci, and there is no significant overlap between YY1 and Ezh2 targets, suggensting a Ezh2-independent manner. Further detailed study revealed that YY1 can regulate some lincRNAs which are fucntional in skeletal myogenesis. In this study, we identified a YY1-Yam-1-miR-715 (TF-lincRNA-miRNA) regulatory curcuit in myogensis.
 
Overall design Examination of YY1 targets in myoblast versus myotubes
 
Contributor(s) Wang H, Sun H, Lu L, Sun K, Chen X, Wang L, Zhao Y, Zhou L
Citation(s) 23942234, 26484078
Submission date Apr 08, 2013
Last update date May 15, 2019
Contact name Kun Sun
E-mail(s) sunkun@szbl.ac.cn
Organization name Shenzhen Bay Laboratory
Department Cancer Research
Lab Kun Sun
Street address Rm B505, No. 9 Duxue Road, Nanshan District
City Shenzhen
ZIP/Postal code 518107
Country China
 
Platforms (2)
GPL11002 Illumina Genome Analyzer IIx (Mus musculus)
GPL13112 Illumina HiSeq 2000 (Mus musculus)
Samples (8)
GSM1117981 YY1_MB_SC1703_ChIP-seq
GSM1117982 YY1_MB_AB58066_ChIP-seq
GSM1117983 YY1_MT_ChIP-seq
Relations
SRA SRP020624
BioProject PRJNA196689

Download family Format
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Supplementary file Size Download File type/resource
GSE45875_RAW.tar 380.0 Kb (http)(custom) TAR (of BEDGRAPH, TXT)
SRA Run SelectorHelp
Raw data are available in SRA
Processed data provided as supplementary file

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