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| Status |
Public on Apr 01, 2006 |
| Title |
Whole-genome expression profiling of melanoma progression. |
| Organism |
Homo sapiens |
| Experiment type |
Expression profiling by array
|
| Summary |
To gain insights into the genetic profile of every stage of the melanoma progression pathway, and to determine to what extent these profiles are similar or distinct, we performed whole-genome expression profiling of tissue specimens representing normal skin, benign and atypical nevi, and early and advanced-stage melanomas. The results of this study provide first-time evidence that significant molecular changes occur distinctly at the border of/transition from melanoma in situ to primary melanoma, and that genes involved in mitotic cell cycle regulation and cell proliferation constitute the two leading categories of genes associated with these changes.
Keywords: Stage comparative analysis
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| Overall design |
Biopsy specimens representing normal skin, nevi, early and advanced stage melanomas, a melanoma cell line, and short-term cultures of human melanocytes and keratinocytes were subjected to whole-genome expression profiling.
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| |
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| Contributor(s) |
Smith AP, Hoek K, Becker D |
| Citation(s) |
16251803 |
| Submission date |
Mar 31, 2006 |
| Last update date |
Mar 25, 2019 |
| Contact name |
Dorothea Becker |
| E-mail(s) |
dbecker@pitt.edu
|
| Organization name |
University of Pittsburgh
|
| Department |
Department of Pathology
|
| Street address |
5117 Centre Avenue
|
| City |
Pittsburgh |
| State/province |
PA |
| ZIP/Postal code |
15213-1863 |
| Country |
USA |
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| Platforms (1) |
| GPL570 |
[HG-U133_Plus_2] Affymetrix Human Genome U133 Plus 2.0 Array |
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| Samples (18)
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| Relations |
| BioProject |
PRJNA94437 |
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