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Series GSE4571 Query DataSets for GSE4571
Status Public on May 31, 2006
Title Expression profiling of Treg cell versus their controls in human and mouse
Organisms Homo sapiens; Mus musculus
Experiment type Expression profiling by array
Summary We applied Affymetrix GeneChip technology for expression profiling of CD4+CD25+ (Treg) T cells versus their naive CD4+CD25- controls to obtain more information about the underlying molecular mechanisms involved in Treg specific immune suppression
Keywords: cell type comparison
Overall design Expression profiles from:

[1] human Treg cells obtained from peripheral blood by cell sorting were compared to their naive controls. RNAs were prepared from pools of ten individual healthy donors, labeled in two independend labeling reactions and hybridized onto two GeneChips of the same lot.

[2] mouse Treg cells obtained from spleen by cell sorting of Balb/c mice were compared to their naive controls. RNAs were prepared from pools of three individual Balb/c mice, labeled in three independend labeling reactions and hybridized onto three GeneChips of the same lot.

The differences in gene expression were used to unravel molecular mechanisms that help to explain the suppressive and anergic phenotypes of Treg cells after antigen activation.
Contributor(s) Geffers R, Hansen W, Probst-Kepper M, Buer J
Citation(s) 16836768
Submission date Mar 29, 2006
Last update date Jan 08, 2019
Contact name Robert Geffers
Phone +49 531-6181-3058
Organization name HCI - Helmholtz Centre for Infection Research
Department Dep. Molecular Bacteriology
Lab Genome Analytics
Street address Inhoffenstr. 7
City Braunschweig
ZIP/Postal code 38124
Country Germany
Platforms (3)
GPL96 [HG-U133A] Affymetrix Human Genome U133A Array
GPL97 [HG-U133B] Affymetrix Human Genome U133B Array
GPL339 [MOE430A] Affymetrix Mouse Expression 430A Array
Samples (14)
GSM102099 CD4+ CD25+_1 (HG-U133A)
GSM102100 CD4+ CD25+_1 (HG-U133B)
GSM102101 CD4+ CD25-_1 (HG-U133A)
BioProject PRJNA94405

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Supplementary data files not provided

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