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Series GSE4570 Query DataSets for GSE4570
Status Public on Mar 30, 2006
Title Expression profiling reveals novel pathways in the transformation of melanocytes to melanomas.
Organism Homo sapiens
Experiment type Expression profiling by array
Summary Affymetrix oligonucleotide microarrays were used to assess global differential gene expression comparing normal human melanocytes with six independent melanoma cell strains from advanced lesions. The data, validated at the protein level for selected genes, confirmed the overexpression in melanoma cells relative to normal melanocytes of several genes in the growth factor/receptor family that confer growth advantage and metastasis. In addition, novel pathways and patterns of associated expression in melanoma cells not reported before emerged.
Keywords: class comparison study (melanoma vs melanocyte)
Overall design Six melanoma cultures and two melanocyte cultures. The melanoma cultures are considered, for the purposes of this investigation, replicates from the point of view that they are all melanomas.
Contributor(s) Hoek K, Rimm DL, Williams KR, Zhao H, Ariyan S, Lin A, Kluger HM, Berger AJ, Cheng E, Trombetta S, Wu T, Niinobe M, Yoshikawa K, Hannigan GE, Halaban R
Citation(s) 15289333
Submission date Mar 29, 2006
Last update date Aug 10, 2018
Contact name Keith S Hoek
Organization name Currently unaffilliated
Street address private
City Z├╝rich
ZIP/Postal code 8004
Country Switzerland
Platforms (1)
GPL96 [HG-U133A] Affymetrix Human Genome U133A Array
Samples (8)
GSM102065 WW165
BioProject PRJNA94403

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