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Series GSE45574 Query DataSets for GSE45574
Status Public on Mar 06, 2016
Title H2ABbd ChIP-seq and MeDIP sequence result
Organism Mus musculus
Experiment type Genome binding/occupancy profiling by high throughput sequencing
Methylation profiling by high throughput sequencing
Summary H2ABbd is a unique histone H2A variant that shares only 40 ~ 50 % sequence identity with canonical H2A. It has only been identified in mammals and has quickly evolved with remarkable sequence diversity among different species. H2ABbd is ubiquitously expressed in most cells and tissues. It is mainly deposited in gene body region.The localization of H2ABbd is associated with methylated CpG islands in mouse ES cells.H2ABbd facilitates transcription elongation to go through methylated CpG islands in the gene bodies. One typical example is that H2ABbd regulates transcription elongation at imprinted loci.
Overall design We found H2ABbd enriched in some methylated loci. Using ChIP-seq and MeDIP-seq, we test the correlation of H2ABbd and DNA methylation.
Contributor(s) Chen Y, Yu X
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Submission date Mar 28, 2013
Last update date May 15, 2019
Contact name Yibin Chen
Organization name university of Michigan
Lab Xiaochun Yu
Street address 1115 w medical drive
City Ann Arbor
State/province MI
ZIP/Postal code 48104
Country USA
Platforms (1)
GPL13112 Illumina HiSeq 2000 (Mus musculus)
Samples (2)
GSM1109946 H2ABbd ChIP-seq result
GSM1109947 MeDIP result
BioProject PRJNA194610
SRA SRP020227

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Series Matrix File(s) TXTHelp

Supplementary file Size Download File type/resource
GSE45574_RAW.tar 192.9 Mb (http)(custom) TAR (of BED)
SRA Run SelectorHelp
Raw data are available in SRA
Processed data provided as supplementary file

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