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Series GSE45539 Query DataSets for GSE45539
Status Public on May 21, 2018
Title miRNA signature of young, replicative and TNF-α-induced premature senescent of human microvascular endothelial cells-lung (HMVEC-L)
Organism Homo sapiens
Experiment type Non-coding RNA profiling by array
Summary Despite the fact that miRNAs have been extensively investigated for their involvement in diseases, senescence as well as inflammation, miRNAs involved in TNF-α- induced premature senescence remain to be uncovered. Hence, the present study aims to identify unique miRNAs and their respective signaling pathways in TNF-α-induced senescence in lung microvascular endothelial cells and novel targets for prevention or protection against premature senescence and endothelial hyperpermeability. We have employed Agilent Human MicroRNAs microarray platform to evaluate the expressions of 866 human miRNAs and 89 human viral miRNAs, based on Sanger miRNA database release 12.0.
Overall design miRNA expression profiles were established for young, replicative and TNF-α-induced premature senescent of HMVEC-L.
Contributor(s) Jong H, Mustafa MR, AbuBakar S, Wong P
Citation(s) 28595801
Submission date Mar 27, 2013
Last update date May 22, 2018
Contact name Pooi-Fong Wong
Organization name University of malaya
Department Pharmacology
Street address Faculty of Medicine
ZIP/Postal code 50603
Country Malaysia
Platforms (1)
GPL14767 Agilent-021827 Human miRNA Microarray G4470C (Feature Number version)
Samples (8)
GSM1108289 HMVEC-L_young_rep1
GSM1108290 HMVEC-L_young_rep2
GSM1108291 HMVEC-L_replicative senescent_rep1
This SubSeries is part of SuperSeries:
GSE45541 Young, replicative and TNF-a-induced premature senescent of human microvascular endothelial cells-lung (HMVEC-L)
BioProject PRJNA194550

Download family Format
SOFT formatted family file(s) SOFTHelp
MINiML formatted family file(s) MINiMLHelp
Series Matrix File(s) TXTHelp

Supplementary file Size Download File type/resource
GSE45539_RAW.tar 6.6 Mb (http)(custom) TAR (of TXT)
Processed data included within Sample table
Processed data provided as supplementary file

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