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Series GSE44904 Query DataSets for GSE44904
Status Public on May 10, 2013
Title mRNAs and miRNAs expression data from AOM/DSS, AOM, DSS and control mouse colon epithelial tissue at day100 when tumor formed in AOM/DSS bearing mice --- mRNA expression data
Organism Mus musculus
Experiment type Expression profiling by array
Summary To find out which mRNAs are significantly differential expression and potentially involved in the process of inflammation promoting carcinogenesis of colorectal cancer (CRC). We established a colitis-associated CRC (AOM/DSS, Azoxymethane/Dextran sulfate sodium salt) model, colitis (DSS) model and high dose carcinogen (AOM, about 5 times AOM amount given than AOM/DSS model) model. At day 100 when tumor formed in AOM/DSS bearing mice (colitis-associated CRC mice) but no tumor was found in AOM (high dose carcinogen) and DSS model, we employed whole genome microarray expression profiling as a discovery platform to identify genes with the potential to involve in the progression of CRC promoted by inflammation.
 
Overall design 5-7 weeks female BALB/c mice, (1) AOM/DSS group: AOM 12.5mg/kg i.p. at day 1, DSS drinking 5d/21dx3circles from day 5; (2) AOM group: AOM 10mg/kg i.p. 1/weekx6 from day 1; (3) DSS group: DSS drinking 5d/21dx3circles from day 5. The distal colon epithelial tissues were collected at day100 when tumor formed in AOM/DSS bearing mice. The whole genome microarray expression profiling experiments were performed together.
 
Contributor(s) Zhang Y, Gao Y
Citation(s) 23615396
Submission date Mar 05, 2013
Last update date Jan 12, 2017
Contact name yanqiao zhang
E-mail(s) 33639877@qq.com
Organization name Harbin Medical University Cancer Hospital
Street address Haping Road # 150, Nangang District,Harbin, Heilongjiang Province, P. R. China
City Harbin
State/province Heilongjiang
ZIP/Postal code 150086
Country China
 
Platforms (1)
GPL7202 Agilent-014868 Whole Mouse Genome Microarray 4x44K G4122F (Probe Name version)
Samples (12)
GSM1093784 DisColoEpithelium_AOM_rep1
GSM1093785 DisColoEpithelium_AOM_rep2
GSM1093786 DisColoEpithelium_AOM_rep3
This SubSeries is part of SuperSeries:
GSE44988 mRNAs and miRNAs expression data from AOM/DSS, AOM, DSS and control mouse colon epithelial tissue at day100 when tumor formed in AOM/DSS bearing mice
Relations
BioProject PRJNA192715

Download family Format
SOFT formatted family file(s) SOFTHelp
MINiML formatted family file(s) MINiMLHelp
Series Matrix File(s) TXTHelp

Supplementary file Size Download File type/resource
GSE44904_RAW.tar 26.3 Mb (http)(custom) TAR (of TXT)
Processed data included within Sample table

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