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Series GSE44661 Query DataSets for GSE44661
Status Public on Sep 19, 2013
Title DNA methylation analysis of melanoma progression to brain metastasis
Organism Homo sapiens
Experiment type Methylation profiling by array
Summary Melanoma is one of the most aggressive and treatment-resistant cancers. It represents the most life-threatening neoplasm of the skin, and its incidence has been increasing for the last three decades. Melanoma evolves from the local transformation of melanocytes to primary tumors, which can metastasize to multiple organs. Brain metastases represent one of the most significant causes of death in cutaneous melanoma patients. Despite aggressive multi-modality threapy, patients with melanoma brain metastasis have a median survival of less than a year, with a majority of these patients dying as a result of their intracranial disease. We aimed to find brain metastasis-specific molecular markers. To identify alterations in DNA methylation related to brain metastasis, we used Illumina 450K BeadChips to assess differentially methylated regions in melanocytes, primary melanomas, lymph node metastases, and brain metastases.
Overall design Bisulphite-converted DNA from 40 specimens was hybridised to the Illumina Infinium 450k Human Methylation BeadChip.
Contributor(s) Hoon D, Huang S
Citation(s) 24014427
Submission date Feb 25, 2013
Last update date Mar 22, 2019
Contact name Dave S.B. Hoon
Organization name Saint John's Cancer Institute
Department Translational Molecular Medicine
Street address 2200 Santa Monica Boulevard
City Santa Monica
State/province CA
ZIP/Postal code 90403
Country USA
Platforms (1)
GPL13534 Illumina HumanMethylation450 BeadChip (HumanMethylation450_15017482)
Samples (40)
GSM1088514 Genomic DNA from melanocyte 1
GSM1088515 Genomic DNA from melanocyte 2
GSM1088516 Genomic DNA from melanocyte 3
This SubSeries is part of SuperSeries:
GSE44662 Genome-wide DNA methylation, gene expression, and copy number integrative analysis of melanoma brain metastasis
BioProject PRJNA190805

Download family Format
SOFT formatted family file(s) SOFTHelp
MINiML formatted family file(s) MINiMLHelp
Series Matrix File(s) TXTHelp

Supplementary file Size Download File type/resource
GSE44661_RAW.tar 183.1 Mb (http)(custom) TAR
GSE44661_methylated_unmethylated_signals.txt.gz 209.0 Mb (ftp)(http) TXT
Processed data included within Sample table

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