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Series GSE44637 Query DataSets for GSE44637
Status Public on Feb 05, 2014
Title CTCF binding in B cells and Plasmablasts
Organism Mus musculus
Experiment type Genome binding/occupancy profiling by high throughput sequencing
Summary The mammalian CCCTC-binding factor (CTCF) regulates gene expression through the formation of higher order chromatin structures. Recent evidence has implicated a role for CTCF in regulating gene expression in the human MHCII locus. To investigate the role of CTCF in murine MHCII gene expression we mapped CTCF binding sites in B cells (MHCII+ cells) and Plasmablasts which are differentiated B cells that have silenced MHCII gene expression. These observations lead to the identification of differential CTCF binding during differentiation in these cell types and suggest mechanims of MHCII gene regulation.
Overall design Comparison of CTCF binding in B cells and Plasmablasts in mice using ChIP-seq
Contributor(s) Scharer C, Boss J
Citation(s) 24634495
Submission date Feb 25, 2013
Last update date May 15, 2019
Contact name Chris Scharer
Organization name Emory University
Department Microbiology and Immunology
Lab Chris Scharer
Street address 1510 Clifton Rd, Suite 3086A
City Atlanta
State/province GA
ZIP/Postal code 30322
Country USA
Platforms (2)
GPL9250 Illumina Genome Analyzer II (Mus musculus)
GPL13112 Illumina HiSeq 2000 (Mus musculus)
Samples (4)
GSM1088169 B cell CTCF
GSM1088170 B cell Input
GSM1088171 Plasmablast CTCF
SRA SRP018843
BioProject PRJNA191092

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Series Matrix File(s) TXTHelp

Supplementary file Size Download File type/resource
GSE44637_RAW.tar 291.0 Mb (http)(custom) TAR (of BEDGRAPH, TXT)
SRA Run SelectorHelp
Raw data are available in SRA
Processed data provided as supplementary file

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