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Series GSE44366 Query DataSets for GSE44366
Status Public on Oct 23, 2013
Title Transcriptome along the murine developing gut
Organism Mus musculus
Experiment type Expression profiling by high throughput sequencing
Summary Hox genes are required for the development of the intestinal caecum, a major organ of species eating plants. We have analysed the transcriptional regulation of Hoxd genes in caecal buds and show that they are controlled by a series of enhancers located in a gene desert telomeric to the HoxD cluster. The start site of two neighboring and opposite long non-coding RNAs, Hotdog and Twin of Hotdog, specifically transcribed in the caecum, contacts the expressed Hoxd genes in the framework of a topological domain, a large domain of interactions, which ensures a robust transcription of these genes during caecum budding. We show that hedgehogs have kept this regulatory potential despite the absence of caecum, suggesting that these enhancers are used in other developmental situations. In this context, we discuss some striking similarities between the caecum and the limb buds, suggesting the implementation of a common budding tool-kit.
Overall design Transcriptional activity at the HoxD locus in the murine developing gut at E13, Differential gene expression analysis along the murine developing gut
Contributor(s) Delpretti S, Duboule D
Citation(s) 24075990
Submission date Feb 15, 2013
Last update date May 15, 2019
Contact name Marion LELEU
Organization name EPFL
Department School of Life Sciences
Lab Laboratory of developmental genomics
Street address EPFL-SV-ISREC-UPDUB- Station 19
City Lausanne
ZIP/Postal code 1015
Country Switzerland
Platforms (1)
GPL13112 Illumina HiSeq 2000 (Mus musculus)
Samples (3)
GSM1083970 Mouse Ileum
GSM1083971 Mouse Colon
GSM1083972 Mouse Caecum
This SubSeries is part of SuperSeries:
GSE45242 HoxD locus
SRA SRP018707
BioProject PRJNA193402

Download family Format
SOFT formatted family file(s) SOFTHelp
MINiML formatted family file(s) MINiMLHelp
Series Matrix File(s) TXTHelp

Supplementary file Size Download File type/resource
GSE44366_Mu_ca_co_il_genes_expression.txt.gz 2.0 Mb (ftp)(http) TXT
GSE44366_RAW.tar 610.7 Mb (http)(custom) TAR (of BW)
SRA Run SelectorHelp
Raw data are available in SRA
Processed data provided as supplementary file
Processed data are available on Series record

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