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Series GSE43776 Query DataSets for GSE43776
Status Public on Apr 28, 2013
Title The interactome of POU5F1 upstream enhancer in mouse embryonic stem cells revealed by 4C-Seq
Organism Mus musculus
Experiment type Other
Summary We report the application of 4C-Seq technique for exploring POU5F1 enhancer interactome in mouse embryonic stem cells. A statistical model was built to identify enriched interacting regions from raw 4C data. The biological replicate data were compared to identify reproducible interacting regions. The interacting sites in the reproducible regions are enriched with active histone marks as well as transcription factors Oct4, Klf4, Esrrb, Tcfcp2i1 and Zfx that are critical for reprogramming and pluripotency.
Overall design Generation of Illumina HiSeq2000 sequencing data using 4C-Seq protocol
Contributor(s) Gao F, Wei Z, Wang K, Lu W
Citation(s) 23705979
Submission date Jan 25, 2013
Last update date May 15, 2019
Contact name Fan Gao
Organization name USC
Department ZNI
Street address 1501 San Pablo St. ZNI 245
City Los Angeles
State/province California
ZIP/Postal code 90033
Country USA
Platforms (1)
GPL13112 Illumina HiSeq 2000 (Mus musculus)
Samples (2)
GSM1070867 POU5F1_sonication_replicate1_4C-Seq
GSM1070868 POU5F1_sonication_replicate2_4C-Seq
BioProject PRJNA187390
SRA SRP018230

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Supplementary file Size Download File type/resource
GSE43776_sonicate_4C_sites_reproducible_regions.bed.gz 8.0 Kb (ftp)(http) BED
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