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Series GSE43638 Query DataSets for GSE43638
Status Public on Apr 03, 2013
Title Molecular and Genetic Crosstalks Between mTOR and ERRα are Key Determinants of Rapamycin-induced Non-Alcoholic Fatty Liver.
Organism Mus musculus
Experiment type Genome binding/occupancy profiling by high throughput sequencing
Summary mTOR and ERRα are key regulators of common metabolic processes. However, the extent of functional overlap between these two factors has not been investigated. ChIP-sequencing analyses on mouse liver reveal mTOR recruitment to regulatory regions of genes on a genome-wide scale including enrichment at genes shared with ERRα that are involved in the TCA cycle and lipogenesis pathway. A total of 9469 and 23226 peaks were identified for mTOR and ERRα ChIP-seq datasets, respectively.
Overall design mTOR and ERRα mouse liver ChIP-seq datasets obtained from pooling 8 individual ChIPs from a chromatin pool of 26 livers.
Contributor(s) Chaveroux C, Eichner LJ, Dufour CR, Shatnawi A, Khoutorsky A, Bourque G, Sonenberg N, Giguère V
Citation(s) 23562079, 38537884
Submission date Jan 18, 2013
Last update date Apr 17, 2024
Contact name Vincent Giguère
Organization name McGill University
Department Biochemistry, Medicine and Oncology
Street address 1160 Pine Avenue West, room 710A
City Montréal
State/province Québec
ZIP/Postal code H3A 1A3
Country Canada
Platforms (1)
GPL13112 Illumina HiSeq 2000 (Mus musculus)
Samples (3)
GSM1067407 mTOR mouse liver ChIP-seq
GSM1067408 ERRα mouse liver ChIP-seq
GSM1067409 Rabbit IgG mouse liver ChIP-seq
BioProject PRJNA186874
SRA SRP018042

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SOFT formatted family file(s) SOFTHelp
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Series Matrix File(s) TXTHelp

Supplementary file Size Download File type/resource
GSE43638_RAW.tar 150.3 Mb (http)(custom) TAR (of TXT)
SRA Run SelectorHelp
Raw data are available in SRA
Processed data provided as supplementary file

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