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| Status |
Public on Jun 05, 2013 |
| Title |
Thymidine Kinase and mtDNA Depletion in Human Cardiomyopathy: Epigentic and Translational Evidence for Energy Starvation |
| Organism |
Homo sapiens |
| Experiment type |
Expression profiling by array
Methylation profiling by genome tiling array
|
| Summary |
A comparison of epigenetic nuclear DNA methylation and gene expression changes between human dialated cardiomypathy left ventricle samples and non-failing cardiac left ventricule samples
This study addresses how depletion of huaman cardiac left ventricle mitochondrial DNA and epigentic nuclear DNA methylation promote cardiac dysfunction in human dilated cardiomyopathy.
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| |
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| Overall design |
Each sample was fluorescently labeled and hybridized to Roche Nimblegen 2.1M Deluxe Promoter Arrays and Expression arrays.
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| Contributor(s) |
Koczor CA, Lewis W |
| Citation(s) |
23695888, 23695887 |
| Submission date |
Jan 10, 2013 |
| Last update date |
Jun 05, 2013 |
| Contact name |
William Lewis |
| Organization name |
Emory University
|
| Department |
Pathology
|
| Lab |
Lewis Lab
|
| Street address |
101 Woodruff Circle
|
| City |
Atlanta |
| State/province |
Georgia |
| ZIP/Postal code |
30322 |
| Country |
USA |
| |
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| Platforms (2) |
| GPL15338 |
Nimblegen Homo sapiens HG18 Expression Array (12x135k) [gene-level] |
| GPL16284 |
NimbleGen Human DNA Methylation 2.1M Deluxe Promoter Array [100929_HG19_Deluxe_Prom_Meth_HX1] |
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| Samples (40)
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| Relations |
| BioProject |
PRJNA186556 |
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