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| Status |
Public on Jan 25, 2013 |
| Title |
Identification of in vivo, conserved, FUS RNA binding sites and the impact of FUS on the neuronal transcriptome |
| Organisms |
Homo sapiens; Mus musculus |
| Experiment type |
Expression profiling by high throughput sequencing
|
| Summary |
FUS, an RNA binding protein was recently implicated in Amyotrophic Lateral Sclerosis (ALS). ALS is a fatal neurodegenerative disease. We report the identification of the conserved neuronal RNA targets of FUS and the assessment of the impact of FUS depletion on the neuronal transcriptome. We identified that FUS regulates splicing of conserved intron containing transcripts. FUS retains or excludes the conserved intron by binding to them.
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| Overall design |
Identification of FUS neuronal targets using normal human brain samples and mouse neurons
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| |
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| Contributor(s) |
Nakaya T, Alexiou P, Maragkakis M, Chang A, Mourelatos Z |
| Citation(s) |
23389473 |
| Submission date |
Jan 06, 2013 |
| Last update date |
May 15, 2019 |
| Contact name |
Manolis Maragkakis |
| E-mail(s) |
emmanouil.maragkakis@nih.gov
|
| Organization name |
National Institute on Aging
|
| Street address |
251 Bayview Blvd
|
| City |
Baltimore |
| State/province |
MD |
| ZIP/Postal code |
21224 |
| Country |
USA |
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| Platforms (2) |
| GPL9115 |
Illumina Genome Analyzer II (Homo sapiens) |
| GPL11002 |
Illumina Genome Analyzer IIx (Mus musculus) |
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| Samples (11)
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| Relations |
| BioProject |
PRJNA185394 |
| SRA |
SRP017790 |
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