GEO Logo
   NCBI > GEO > Accession DisplayHelp Not logged in | LoginHelp
GEO help: Mouse over screen elements for information.
Series GSE43308 Query DataSets for GSE43308
Status Public on Jan 25, 2013
Title Identification of in vivo, conserved, FUS RNA binding sites and the impact of FUS on the neuronal transcriptome
Organisms Homo sapiens; Mus musculus
Experiment type Expression profiling by high throughput sequencing
Summary FUS, an RNA binding protein was recently implicated in Amyotrophic Lateral Sclerosis (ALS). ALS is a fatal neurodegenerative disease. We report the identification of the conserved neuronal RNA targets of FUS and the assessment of the impact of FUS depletion on the neuronal transcriptome. We identified that FUS regulates splicing of conserved intron containing transcripts. FUS retains or excludes the conserved intron by binding to them.
Overall design Identification of FUS neuronal targets using normal human brain samples and mouse neurons
Contributor(s) Nakaya T, Alexiou P, Maragkakis M, Chang A, Mourelatos Z
Citation(s) 23389473
Submission date Jan 06, 2013
Last update date May 15, 2019
Contact name Manolis Maragkakis
Organization name National Institute on Aging
Street address 251 Bayview Blvd
City Baltimore
State/province MD
ZIP/Postal code 21224
Country USA
Platforms (2)
GPL9115 Illumina Genome Analyzer II (Homo sapiens)
GPL11002 Illumina Genome Analyzer IIx (Mus musculus)
Samples (11)
GSM1060381 FUS_1
GSM1060382 FUS_2
GSM1060383 FUS_3
BioProject PRJNA185394
SRA SRP017790

Download family Format
SOFT formatted family file(s) SOFTHelp
MINiML formatted family file(s) MINiMLHelp
Series Matrix File(s) TXTHelp

Supplementary file Size Download File type/resource
GSE43308_RAW.tar 46.7 Mb (http)(custom) TAR (of BED)
SRA Run SelectorHelp
Raw data are available in SRA
Processed data provided as supplementary file

| NLM | NIH | GEO Help | Disclaimer | Accessibility |
NCBI Home NCBI Search NCBI SiteMap