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Series GSE43275 Query DataSets for GSE43275
Status Public on Apr 23, 2013
Title Genome-wide maps of Sox/Oct partnerships pluripotent and lineage-committed cells
Organism Mus musculus
Experiment type Genome binding/occupancy profiling by high throughput sequencing
Summary We show here by using genome-wide ChIP-sequencing that lineage segregation involves multiple Sox/Oct partnership. In undifferentiated ES cells Oct4 interacts with Sox2 and both TFs bind on the 'canonical' motif, whereas in cells commited to PrE lineage Oct4 switches from Sox2 to Sox17 interaction and this complex bind to a unique "compressed" motif.
Overall design ChIP-sequencing has been done for Sox2, Sox17 and Oct4 in the pluripotent context or PrE context
Contributor(s) Aksoy I, Stanton L
Citation(s) 23474895
Submission date Jan 03, 2013
Last update date May 15, 2019
Contact name Irene Aksoy
Organization name Stem Cell and Brain Research Institute
Street address 18 avenue du Doyen Lepine
City Lyon
ZIP/Postal code 69500
Country France
Platforms (1)
GPL11002 Illumina Genome Analyzer IIx (Mus musculus)
Samples (20)
GSM1059847 Pou5f1/Oct4_F9 ChIP-seq
GSM1059848 Pou5f1/Oct4_F9+RA ChIP-seq
GSM1059849 Sox17_F9+RA ChIP-seq
SRA SRP017766
BioProject PRJNA185339

Download family Format
SOFT formatted family file(s) SOFTHelp
MINiML formatted family file(s) MINiMLHelp
Series Matrix File(s) TXTHelp

Supplementary file Size Download File type/resource
GSE43275_RAW.tar 728.4 Mb (http)(custom) TAR (of TXT, WIG)
SRA Run SelectorHelp
Raw data are available in SRA
Processed data provided as supplementary file

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