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Series GSE43212 Query DataSets for GSE43212
Status Public on Feb 20, 2013
Title Histone methylation profiles of prospectively isolated mammary epithelial subpopulations
Organism Mus musculus
Experiment type Genome binding/occupancy profiling by high throughput sequencing
Summary In this study we mapped H3K27me3, H3K4me3 and H3K9me2 marks in three mammary epithelial subsets: MaSC/basal (MS), luminal progenitor (LP) and mature luminal (ML) in the steady-state. In addition, profiles were generated for H3K4me3 and H3K27me3 marks in the MaSC/basal and luminal populations from the glands of ovariectomized or mid-pregnant (12.5 days) mice as well as from control virgin mice.
Overall design We used ChIPseq analysis to determine histone modification marks in the MS, LP and ML subsets in the steady-state. We then determined the histone modification profiles of MS and sorted luminal (Lum) cells from pregnant (12.5 dP) or ovariectomized (OVX) mice and compared these with the profiles of control virgin mice in order to study the effect of hormones on the mammary epigenomes.
Contributor(s) Pal B, Bouras T, Shi W, Vaillant F, Sheridan J, Jiang K, Breslin K, Young M, Fu N, Ritchie ME, Lindeman GJ, Smyth GK, Visvader JE
Citation(s) 23375371
Submission date Dec 31, 2012
Last update date May 15, 2019
Contact name Wei Shi
Organization name Olivia Newton-John Cancer Research Institute
Street address 145 Studley Road
City Heidelberg
State/province Victoria
ZIP/Postal code 3084
Country Australia
Platforms (1)
GPL11002 Illumina Genome Analyzer IIx (Mus musculus)
Samples (30)
GSM1058714 MS K4me3 ChIPSeq rep1
GSM1058715 MS K27me3 ChIPSeq rep1
GSM1058716 MS K9me2 ChIPSeq
SRA SRP017714
BioProject PRJNA185275

Download family Format
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Supplementary file Size Download File type/resource
GSE43212_RAW.tar 5.6 Gb (http)(custom) TAR (of BED)
SRA Run SelectorHelp
Raw data are available in SRA
Processed data provided as supplementary file

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