|
| Status |
Public on Aug 23, 2013 |
| Title |
H4K16 acetylation marks active genes and enhancers of embryonic stem cells, but does not alter chromatin compaction (I) [ChIP-Seq] |
| Organism |
Mus musculus |
| Experiment type |
Genome binding/occupancy profiling by high throughput sequencing
|
| Summary |
We report that acetylation of H4K16 is a new marker of active enhancers and that some enhancers are marked by H3K4me1, MOF and H4K16ac but not by acetylated H3K27 or p300, suggesting that they are novel p300-independent regulatory elements.
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| |
|
| Overall design |
ChIP-seq for H4K16 acetylation in undifferentiated ES cells, and cells after 3 days of retinoic acid differentiation, along with MNase digested input for both samples
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| |
|
| Contributor(s) |
Taylor G, Eskeland R, Pradeepa MM, Bickmore W |
| Citation(s) |
23990607 |
| Submission date |
Dec 21, 2012 |
| Last update date |
May 15, 2019 |
| Contact name |
Gillian Taylor |
| E-mail(s) |
G.C.A.Taylor@sms.ed.ac.uk
|
| Organization name |
IGMM
|
| Street address |
MRC HGU Crewe Road South
|
| City |
Edinburgh |
| ZIP/Postal code |
EH4 2XU |
| Country |
United Kingdom |
| |
|
| Platforms (1) |
| GPL11002 |
Illumina Genome Analyzer IIx (Mus musculus) |
|
| Samples (4)
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| This SubSeries is part of SuperSeries: |
| GSE43103 |
H4K16 acetylation marks active genes and enhancers of embryonic stem cells, but does not alter chromatin compaction |
|
| Relations |
| SRA |
SRP017651 |
| BioProject |
PRJNA185201 |
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