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Series GSE43062 Query DataSets for GSE43062
Status Public on Apr 03, 2013
Title Genome wide mapping of histone 3 lysine 79 dimethylation in MLL-AF6 murine leukemias
Organism Mus musculus
Experiment type Genome binding/occupancy profiling by high throughput sequencing
Summary We report the genome wide distribution of H3K79 dimethylation in mouse MLL-AF6 positive leukemias to assess whether this epigenetic mark drives MLL-target gene expression.
Overall design Examination of H3K79 dimethylation in bone marrow cells from sacrificed terminally ill MLL-AF6 positive leukemic mice. The retroviral MSCV-IRES-neo-MLL-AF6 construct was transduced into mouse bone marrow lineage negative Kit +, Sca + (LSK) cells and these cells were injected after G418 selection into irradiated syngenic mice to establish MLL-AF6 positive leukemias.
Contributor(s) Deshpande A, Armstrong S
Citation(s) 23361907
Submission date Dec 20, 2012
Last update date May 15, 2019
Contact name Amit Sinha
Phone 617-582-7579
Organization name Dana-Farber Cancer Institute
Department Pediatric Oncology
Lab Armstrong Lab
Street address 44 Binney St
City Boston
State/province MA
ZIP/Postal code 02135
Country USA
Platforms (1)
GPL13112 Illumina HiSeq 2000 (Mus musculus)
Samples (3)
GSM1055770 H3K79me2_MLL-AF6 rep1
GSM1055771 H3K79me2_MLL-AF6 rep2
GSM1055772 H3K79me2_MLL-AF6 rep3
This SubSeries is part of SuperSeries:
GSE43069 MLL-AF6 leukemia
BioProject PRJNA184352
SRA SRP017628

Download family Format
SOFT formatted family file(s) SOFTHelp
MINiML formatted family file(s) MINiMLHelp
Series Matrix File(s) TXTHelp

Supplementary file Size Download File type/resource
GSE43062_RAW.tar 79.5 Mb (http)(custom) TAR (of WIG)
SRA Run SelectorHelp
Raw data are available in SRA
Processed data provided as supplementary file

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