|
| Status |
Public on Oct 12, 2007 |
| Title |
Genome-Wide Profiling of Airway Epithelial Cells in Asthmatics, Smokers and Healthy Controls |
| Organism |
Homo sapiens |
| Experiment type |
Expression profiling by array
|
| Summary |
We collected airway epithelial brushings for microarray analysis from 42 asthmatics and two control groups – 28 healthy subjects and 16 smokers. A subgroup of 32 asthmatics completed a randomized placebo-controlled trial of fluticasone propionate in which collection of brushings was repeated after 1 week of treatment.
Keywords: disease state analysis, clinical trial
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| |
|
| Overall design |
1) Comparison of gene expression in asthmatics to healthy controls
2) Comparison of smokers to healthy controls
3) Comparison of change in gene expression in the fluticasone treated group to the change in the placebo treated group
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| |
|
| Contributor(s) |
Woodruff PG, Boushey HA, Dolganov GM, Barker CS, Yang YH, Donnelly S, Dao-Pick TP, Erle DJ, Fahy JV |
| Citation(s) |
17898169, 19483109, 20451039, 19628779 |
| Submission date |
Feb 24, 2006 |
| Last update date |
Nov 08, 2019 |
| Contact name |
Prescott Gurney Woodruff |
| E-mail(s) |
prescott.woodruff@ucsf.edu
|
| Phone |
4155142061
|
| Fax |
4154765712
|
| Organization name |
UCSF
|
| Department |
Medicine
|
| Lab |
Woodruff Lab
|
| Street address |
505 Parnassus Ave
|
| City |
San Francisco |
| State/province |
CA |
| ZIP/Postal code |
94143 |
| Country |
USA |
| |
|
| Platforms (1) |
| GPL570 |
[HG-U133_Plus_2] Affymetrix Human Genome U133 Plus 2.0 Array |
|
| Samples (118)
|
|
| Relations |
| BioProject |
PRJNA94683 |
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