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Series GSE42878 Query DataSets for GSE42878
Status Public on Dec 13, 2012
Title Pregnancy-induced gene expression and differentiation of mouse mammary epithelium are co-governed by Nuclear Factor IB (NFIB) and STAT5
Organism Mus musculus
Experiment type Expression profiling by high throughput sequencing
Summary Cytokines control the expression of common and cell-specific genes through the transcription factor STAT5. In mammary tissue specifically, expression of approximately 570 genes is induced during pregnancy by prolactin through STAT5, which binds to putative regulatory sequences. We have now asked whether mammary-specific induction of these genes can be linked to the presence of additional transcription factors, which would act in concert with STAT5. RNA-seq analysis at parturition identified 370 genes that were under NFIB control. Notably, 75% of these genes, encoding proteins linked to the differentiation of mammary epithelium, were also regulated by STAT5. This study demonstrates that the STAT5-NFIB module is an essential part of genes that define differentiation and function of the mammary gland.
Overall design Expression profiling by high throughput sequencing in wild-type (WT) and Nfib-null (KO) mammary gland tissues
Contributor(s) Tang Y, Kang K, Yoo KH, Zhu B, Yamaji D, Gronostajski RM, Robinson G, Hennighausen L
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Submission date Dec 12, 2012
Last update date May 15, 2019
Contact name Keunsoo Kang
Phone 82-41-550-3456
Organization name Dankook University
Department Microbiology
Lab Computational Biology Lab
Street address Dandae-ro 119
City Cheonan
State/province Chungnam
ZIP/Postal code 31116
Country South Korea
Platforms (1)
GPL13112 Illumina HiSeq 2000 (Mus musculus)
Samples (5)
GSM1052699 Nfib-WT rep1
GSM1052700 Nfib-WT rep2
GSM1052701 Nfib-null rep1
BioProject PRJNA183695
SRA SRP017526

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Supplementary file Size Download File type/resource
GSE42878_RPKM.txt.gz 281.8 Kb (ftp)(http) TXT
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