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Series GSE42763 Query DataSets for GSE42763
Status Public on Dec 07, 2012
Title Expression data of multiple sclerosis patients receiving glatiramer acetate therapy [U133 Plus 2.0]
Organism Homo sapiens
Experiment type Expression profiling by array
Summary The purpose of this study was to analyze the transcriptional effects induced by glatiramer acetate treatment (GA; Copaxone, 20 mg injected subcutaneously once daily) in blood monocytes of patients with relapsing-remitting form of multiple sclerosis (MS). By using Affymetrix DNA microarrays, we obtained genome-wide expression profiles of monocytes from 8 MS patients within the first two months of GA administration.
Overall design EDTA blood samples were taken from all patients immediately before first and second GA injection as well as after 1 week, 1 month and 2 months. Total RNA of CD14+ monocytes isolated by magnetic-activated cell sorting (MACS) from each sample was extracted, labeled and hybridized to Affymetrix Human Genome U133 Plus 2.0 arrays to quantify the mRNA levels. This GEO entry provides the U133 Plus 2.0 microarray data.
Contributor(s) Hecker M, Koczan D, Goertsches RH, Zettl UK
Citation(s) 24134771
Submission date Dec 05, 2012
Last update date Jan 17, 2014
Contact name Michael Hecker
Organization name University of Rostock
Department Department of Neurology
Lab Division of Neuroimmunology
Street address Gehlsheimer Str. 20
City Rostock
ZIP/Postal code 18147
Country Germany
Platforms (1)
GPL14837 Affymetrix Human Genome U133 Plus 2.0 Array [CDF: XLab gahgu133plus2_2.1.0]
Samples (37)
GSM1049527 Patient 1, before first GA injection
GSM1049528 Patient 1, before second GA injection
GSM1049529 Patient 1, before week 1 GA injection
BioProject PRJNA183086

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Supplementary file Size Download File type/resource
GSE42763_RAW.tar 197.5 Mb (http)(custom) TAR (of CEL)
Processed data included within Sample table

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