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| Status |
Public on Nov 22, 2012 |
| Title |
Budding yeast Wapl controls sister chromatid cohesion maintenance and the chromosome condensation status [BrdU-ChIP]. |
| Organism |
Saccharomyces cerevisiae |
| Experiment type |
Genome binding/occupancy profiling by genome tiling array
|
| Summary |
Cohesin acetylation by Eco1 during DNA replication establishes sister chromatid cohesion. We show that acetylation makes cohesin resistant to Wapl activity from S-phase until mitosis. Wapl turns out to be a key regulator of cohesin dynamics on chromosomes by controling cohesin maintenance following its establishment in S-phase and its role in chromosome condensation.
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| Overall design |
The Affymetrix Saccharomyces cerevisiae Chip Tiling 1.0F Arrays were used to analyze the incorporation of BrdU in Saccharomyces cerevisiae in S-phase arrested cells.
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| Contributor(s) |
Lopez-Serra L, Lengronne A, Borges V, Kelly G, Uhlmann F |
| Citation(s) |
23219725 |
| |
| Submission date |
Nov 21, 2012 |
| Last update date |
Feb 21, 2013 |
| Contact name |
Rahul Thadani |
| E-mail(s) |
rahul.thadani@cancer.org.uk
|
| Organization name |
Cancer Research UK
|
| Lab |
Chromosome Segregation
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| Street address |
44 Lincoln's Inn Fields
|
| City |
London |
| ZIP/Postal code |
WC2A 3LY |
| Country |
United Kingdom |
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| Platforms (1) |
| GPL7249 |
[Sc03b_MF] Affymetrix GeneChip S. cerevisiae Tiling 1.0F Array |
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| Samples (3) |
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| This SubSeries is part of SuperSeries: |
| GSE42460 |
Budding yeast Wapl controls sister chromatid cohesion maintenance and the chromosome condensation status |
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| Relations |
| BioProject |
PRJNA182010 |
