|
| Status |
Public on Feb 12, 2013 |
| Title |
Next Generation Sequencing Analysis of Wild Type and 53BP1-/- Transcriptomes in B lymphocytes |
| Organism |
Mus musculus |
| Experiment type |
Expression profiling by high throughput sequencing
Genome binding/occupancy profiling by high throughput sequencing
|
| Summary |
Absence of 53BP1 influences the profile of DNA rearrangements in B lymphocytes.To determine whether the differences in translocation partner choice were due to differences in transcription, we compared the transcriptome of 53BP1 deficient and wild-type B cells by RNA-Seq and Polymerase II chromatin immunoprecipitation sequencing (ChIP-Seq).
|
| |
|
| Overall design |
Analysis of total mRNA and PolII loading in the presence or absence of 53BP1 in activated B lymphocytes
|
| |
|
| Contributor(s) |
Jankovic M, Feldhahn N, Oliveira TY, Silva IT, Kieffer-Kwon K, Yamane A, Resch W, Klein I, Robbiani DF, Casellas R, Nussenzweig MC |
| Citation(s) |
23290917 |
| Submission date |
Nov 16, 2012 |
| Last update date |
May 15, 2019 |
| Contact name |
Thiago Y Oliveira |
| E-mail(s) |
toliveira@rockefeller.edu
|
| Organization name |
The Rockefeller University
|
| Department |
Immunology, Virology and Microbiology
|
| Lab |
Laboratory of Molecular Immunology
|
| Street address |
1230 YORK AVE
|
| City |
NEW YORK |
| State/province |
New York |
| ZIP/Postal code |
10065 |
| Country |
USA |
| |
|
| Platforms (1) |
| GPL13112 |
Illumina HiSeq 2000 (Mus musculus) |
|
| Samples (4)
|
|
| Relations |
| BioProject |
PRJNA181137 |
| SRA |
SRP017208 |
Less...
More...