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Series GSE42350 Query DataSets for GSE42350
Status Public on Feb 12, 2013
Title Next Generation Sequencing Analysis of Wild Type and 53BP1-/- Transcriptomes in B lymphocytes
Organism Mus musculus
Experiment type Expression profiling by high throughput sequencing
Genome binding/occupancy profiling by high throughput sequencing
Summary Absence of 53BP1 influences the profile of DNA rearrangements in B lymphocytes.To determine whether the differences in translocation partner choice were due to differences in transcription, we compared the transcriptome of 53BP1 deficient and wild-type B cells by RNA-Seq and Polymerase II chromatin immunoprecipitation sequencing (ChIP-Seq).
Overall design Analysis of total mRNA and PolII loading in the presence or absence of 53BP1 in activated B lymphocytes
Contributor(s) Jankovic M, Feldhahn N, Oliveira TY, Silva IT, Kieffer-Kwon K, Yamane A, Resch W, Klein I, Robbiani DF, Casellas R, Nussenzweig MC
Citation(s) 23290917
Submission date Nov 16, 2012
Last update date May 15, 2019
Contact name Thiago Y Oliveira
Organization name The Rockefeller University
Department Immunology, Virology and Microbiology
Lab Laboratory of Molecular Immunology
Street address 1230 YORK AVE
State/province New York
ZIP/Postal code 10065
Country USA
Platforms (1)
GPL13112 Illumina HiSeq 2000 (Mus musculus)
Samples (4)
GSM1038232 activatedB_wt_polII_chip
GSM1038233 activatedB_53BP1mm_polII_chip
GSM1038234 activatedB_wt_RNASeq
BioProject PRJNA181137
SRA SRP017208

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Supplementary file Size Download File type/resource
GSE42350_RAW.tar 79.0 Mb (http)(custom) TAR (of WIG)
GSE42350_genes.fpkm_tracking.gz 879.5 Kb (ftp)(http) FPKM_TRACKING
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Processed data are available on Series record
Processed data provided as supplementary file
Raw data are available in SRA

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