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Series GSE42148 Query DataSets for GSE42148
Status Public on Nov 09, 2012
Title Global gene expression profile of coronary artery disease in Asian Indians
Organism Homo sapiens
Experiment type Expression profiling by array
Summary Global gene expression profile of whole blood in patients with coronary artery disease (CAD) showed significant upregulation of 343 genes and down regulation of 151 genes as compared to controls (p<0.05). There was predominant differential regulation of inflammatory and immune response genes as well as early growth response genes in our dataset. Of the ten candidate genes selected for validation by real time PCR in an independent cohort, CXCL1, EGR3, IL8, PTGS2 and CD69 genes were up regulated and IFNG and FASLG down regulated in cases relative to controls.
Overall design We selected 13 patients with angiographically confirmed coronary artery disease (CAD) between ages 40 - 55 years and 11 population-based asymptomatic controls with normal ECG and matched for age, gendre and common risk factors such as diabetes and hypertension to that of the cases. Global gene expression profiling was performed on the Agilent microarray platform.
Contributor(s) Arvind P, Shanker J
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Submission date Nov 08, 2012
Last update date Nov 27, 2018
Contact name prathima arvind
Fax 080-27835302
Organization name Thrombosis Research Institute
Department Functional Genomics
Street address #258/A, Bommasandra Industrial Area, Anekal Taluk
City Bangalore
ZIP/Postal code 560099
Country India
Platforms (1)
GPL13607 Agilent-028004 SurePrint G3 Human GE 8x60K Microarray (Feature Number version)
Samples (24)
GSM1033576 Peripheral Blood, control 1, 14hrs fasting , rep 1
GSM1033577 Peripheral Blood, control 2, 14hrs fasting , rep 1
GSM1033578 Peripheral Blood, control 3, 14hrs fasting , rep 1
BioProject PRJNA179208

Download family Format
SOFT formatted family file(s) SOFTHelp
MINiML formatted family file(s) MINiMLHelp
Series Matrix File(s) TXTHelp

Supplementary file Size Download File type/resource
GSE42148_RAW.tar 80.1 Mb (http)(custom) TAR (of TXT)
Processed data included within Sample table
Processed data provided as supplementary file

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