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| Status |
Public on Nov 09, 2012 |
| Title |
Global gene expression profile of coronary artery disease in Asian Indians |
| Organism |
Homo sapiens |
| Experiment type |
Expression profiling by array
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| Summary |
Global gene expression profile of whole blood in patients with coronary artery disease (CAD) showed significant upregulation of 343 genes and down regulation of 151 genes as compared to controls (p<0.05). There was predominant differential regulation of inflammatory and immune response genes as well as early growth response genes in our dataset. Of the ten candidate genes selected for validation by real time PCR in an independent cohort, CXCL1, EGR3, IL8, PTGS2 and CD69 genes were up regulated and IFNG and FASLG down regulated in cases relative to controls.
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| Overall design |
We selected 13 patients with angiographically confirmed coronary artery disease (CAD) between ages 40 - 55 years and 11 population-based asymptomatic controls with normal ECG and matched for age, gendre and common risk factors such as diabetes and hypertension to that of the cases. Global gene expression profiling was performed on the Agilent microarray platform.
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| Contributor(s) |
Arvind P, Shanker J |
| Citation missing |
Has this study been published? Please login to update or notify GEO. |
| Submission date |
Nov 08, 2012 |
| Last update date |
Nov 27, 2018 |
| Contact name |
prathima arvind |
| E-mail(s) |
prathima79@gmail.com
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| Fax |
080-27835302
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| Organization name |
Thrombosis Research Institute
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| Department |
Functional Genomics
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| Street address |
#258/A, Bommasandra Industrial Area, Anekal Taluk
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| City |
Bangalore |
| ZIP/Postal code |
560099 |
| Country |
India |
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| Platforms (1) |
| GPL13607 |
Agilent-028004 SurePrint G3 Human GE 8x60K Microarray (Feature Number version) |
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| Samples (24)
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| GSM1033576 |
Peripheral Blood, control 1, 14hrs fasting , rep 1 |
| GSM1033577 |
Peripheral Blood, control 2, 14hrs fasting , rep 1 |
| GSM1033578 |
Peripheral Blood, control 3, 14hrs fasting , rep 1 |
| GSM1033579 |
Peripheral Blood, control 4, 14hrs fasting , rep 1 |
| GSM1033580 |
Peripheral Blood, control 5, 14hrs fasting , rep 1 |
| GSM1033581 |
Peripheral Blood, control 6, 14hrs fasting , rep 1 |
| GSM1033582 |
Peripheral Blood, control 7, 14hrs fasting , rep 1 |
| GSM1033583 |
Peripheral Blood, control 8, 14hrs fasting , rep 1 |
| GSM1033584 |
Peripheral Blood, control 9, 14hrs fasting , rep 1 |
| GSM1033585 |
Peripheral Blood, control 10, 14hrs fasting , rep 1 |
| GSM1033586 |
Peripheral Blood, control 11, 14hrs fasting , rep 1 |
| GSM1033587 |
Peripheral Blood, SA 1, 14hrs fasting , rep 1 |
| GSM1033588 |
Peripheral Blood, SA 2, 14hrs fasting , rep 1 |
| GSM1033589 |
Peripheral Blood, SA 3, 14hrs fasting , rep 1 |
| GSM1033590 |
Peripheral Blood, SA 4, 14hrs fasting , rep 1 |
| GSM1033591 |
Peripheral Blood, SA 5, 14hrs fasting , rep 1 |
| GSM1033592 |
Peripheral Blood, SA 6, 14hrs fasting , rep 1 |
| GSM1033593 |
Peripheral Blood, SA 7, 14hrs fasting , rep 1 |
| GSM1033594 |
Peripheral Blood, MI 1, 14hrs fasting , rep 1 |
| GSM1033595 |
Peripheral Blood, MI 2, 14hrs fasting , rep 1 |
| GSM1033596 |
Peripheral Blood, MI 3, 14hrs fasting , rep 1 |
| GSM1033597 |
Peripheral Blood, MI 4, 14hrs fasting , rep 1 |
| GSM1033598 |
Peripheral Blood, MI 5, 14hrs fasting , rep 1 |
| GSM1033599 |
Peripheral Blood, MI 6, 14hrs fasting , rep 1 |
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| Relations |
| BioProject |
PRJNA179208 |
| Supplementary file |
Size |
Download |
File type/resource |
| GSE42148_RAW.tar |
80.1 Mb |
(http)(custom) |
TAR (of TXT) |
| Processed data included within Sample table |
| Processed data provided as supplementary file |
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