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| Status |
Public on Feb 01, 2013 |
| Title |
Gene expression profile of the human leukemia cell line Reh after treatment with bortezomib, valproic acid or a combination of both. |
| Organism |
Homo sapiens |
| Experiment type |
Expression profiling by array
|
| Summary |
New therapy options are required for relapsed B-cell precursor ALL patients in order to improve survival and reduce adverse acute and late effects. We observed a synergistic anti-leukemic activity of concomitant treatment with bortezomib and valproic acid in BCP-ALL cells. In this experiment we aimed to identify the pathways modulated after concomitant treatment with bortezomib and valproic acid.
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| Overall design |
Reh cells treated with either bortezomib, valproic acid, or the combination of both normalized to a untreated control.
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| |
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| Contributor(s) |
Shalapour S |
| Citation(s) |
23357978 |
| Submission date |
Oct 31, 2012 |
| Last update date |
Nov 27, 2018 |
| Contact name |
Shabnam Shalapour |
| E-mail(s) |
shabnam.shalapour@charite.de
|
| Organization name |
Charité - Universitätsmedizin Berlin
|
| Street address |
Augustenburger Platz 1
|
| City |
Berlin |
| ZIP/Postal code |
13353 |
| Country |
Germany |
| |
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| Platforms (1) |
| GPL13607 |
Agilent-028004 SurePrint G3 Human GE 8x60K Microarray (Feature Number version) |
|
| Samples (4)
|
| GSM1028107 |
Reh cells_valproic acid and bortezomib_12h |
|
| Relations |
| BioProject |
PRJNA178578 |
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