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Series GSE41933 Query DataSets for GSE41933
Status Public on Feb 04, 2015
Title Human bone and marrow niche formation by mesenchymal progenitors in vivo is predefined by an organotypic epigenetic signature
Organism Homo sapiens
Experiment type Methylation profiling by array
Summary In this study, we have analyzed DNA methylation characteristics of human mesenchymal stem and progenitor cells (MSPCs) form different tissue sources including bone marrow (BM), white adipose tissue (WAT ), umbilical cord (UC) as well as dermal fibroblasts by using the HumanMethylation450K array. Cells able to form bone through endochondral ossification and attract bone marrow in an innovative in vivo model were compared to cells lacking these capacities. Interestingly only BM-derived MSPCs were capable of bone formation and marrow attraction. These features correlated with unique epigenetic characteristics potentially enabling BM-derived cells to undergo endochondral ossification.
Overall design 12 samples were hybridised to the Illumina Infinium 450k Human Methylation Beadchip
Contributor(s) Reinisch A, Etchart N, Hofmann NA, Fruehwirth M, Ortner A, Thaler D, Feilhauer B, Hartwig UF, Beham-Schmid C, Trajanoski S, Wagner W, Lin Q, Dullin C, Alves F, Schallmoser K, Andreeff M, Strunk D
Citation(s) 25406351
Submission date Oct 31, 2012
Last update date Mar 22, 2019
Contact name Andreas Reinisch
Phone +43 31638572930
Organization name Medical University of Graz
Department Dept. of Internal Medicine, Division of Hematology, Stem Cell Research Unit
Street address Auenbruggerplatz 38
City Graz
ZIP/Postal code 8036
Country Austria
Platforms (1)
GPL13534 Illumina HumanMethylation450 BeadChip (HumanMethylation450_15017482)
Samples (12)
GSM1027664 AT_MSC_1
GSM1027665 AT_MSC_2
GSM1027666 AT_MSC_3
BioProject PRJNA178541

Download family Format
SOFT formatted family file(s) SOFTHelp
MINiML formatted family file(s) MINiMLHelp
Series Matrix File(s) TXTHelp

Supplementary file Size Download File type/resource
GSE41933_RAW.tar 183.1 Mb (http)(custom) TAR
GSE41933_signal_intensities.txt.gz 50.9 Mb (ftp)(http) TXT
Processed data included within Sample table

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