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Series GSE41826 Query DataSets for GSE41826
Status Public on Feb 22, 2013
Title A Cell Epigenotype Specific Model for the Correction of Cellular Heterogeneity in the Brain
Organism Homo sapiens
Experiment type Methylation profiling by array
Summary Cellular heterogeneity may bias cell type specific epigenetic patterns leading to a dramatic increase in false positive or negative findings in psychiatric epigenetic studies. To address this issue, we performed fluorescence activated cell sorting (FACS) of neuronal nuclei in post mortem frontal cortex 58 samples followed by Illumina HM450 microarray based DNA methylation profiling. We characterized the extent of neuron and glia specific DNA methylation variation independent of disease status and identified significant cell type specific epigenetic variation at 51% of loci.
Overall design DNA methylation was profiled for sorted neuronal nuclei from post mortem frontal cortex of 29 major depression and 29 matched control samples using Illumina HM450 microarrays
Contributor(s) Guintivano J, Aryee MJ, Kaminsky Z
Citation(s) 23426267
Submission date Oct 24, 2012
Last update date Mar 22, 2019
Contact name Jerry Guintivano
Organization name Johns Hopkins University
Street address 720 Rutland Avenue, Ross 1068
City Baltimore
State/province MD
ZIP/Postal code 21205
Country USA
Platforms (1)
GPL13534 Illumina HumanMethylation450 BeadChip (HumanMethylation450_15017482)
Samples (145)
GSM1024873 5175-G
GSM1024874 5175-N
GSM1024875 813-N
BioProject PRJNA178244

Download family Format
SOFT formatted family file(s) SOFTHelp
MINiML formatted family file(s) MINiMLHelp
Series Matrix File(s) TXTHelp

Supplementary file Size Download File type/resource
GSE41826_FinalReport_zkaminsky_CETStrimmed.txt.gz 1.1 Gb (ftp)(http) TXT
GSE41826_RAW.tar 183.1 Mb (http)(custom) TAR
Processed data included within Sample table

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