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Series GSE41651 Query DataSets for GSE41651
Status Public on Nov 15, 2012
Title Characterization of the EZH2-MMSET histone methyltransferase regulatory axis in cancer [expression]
Organism Homo sapiens
Experiment type Expression profiling by array
Summary Histone methyltransferases (HMTases), as chromatin modifiers, regulate the transcriptomic landscape in normal development as well in diseases such as cancer. Here, we molecularly order two HMTases, EZH2 and MMSET that have established genetic links to oncogenesis. EZH2, which mediates histone H3K27 trimethylation and is associated with gene silencing, was shown to be coordinately expressed and function upstream of MMSET, which mediates H3K36 dimethylation and is associated with active transcription. We found that the EZH2-MMSET HMTase axis is coordinated by a microRNA network and that the oncogenic functions of EZH2 require MMSET activity. Together, these results suggest that the EZH2-MMSET HMTase axis coordinately functions as a master regulator of transcriptional repression, activation, and oncogenesis and may represent an attractive therapeutic target in cancer.
Overall design LacZ control vs MMSET overexpression or MMSET DeltaSET overexpression in replicates
Contributor(s) Jing X, Asangani IA
Citation(s) 23159737
Submission date Oct 17, 2012
Last update date Feb 22, 2018
Contact name Meng Zhao
Phone 404-712-8611
Organization name Emory University
Department BIOS
Lab Steve Qin
Street address 1518 Clifton Rd, #369
City Atlanta
State/province GA
ZIP/Postal code 30322
Country USA
Platforms (1)
GPL4133 Agilent-014850 Whole Human Genome Microarray 4x44K G4112F (Feature Number version)
Samples (6)
GSM1020995 MMSET overexpression in H16N2 Cell Replicate 1
GSM1020996 MMSET overexpression in H16N2 Cell Replicate 2
GSM1020997 MMSET overexpression in HME Cell Replicate 1
This SubSeries is part of SuperSeries:
GSE41653 Characterization of the EZH2-MMSET histone methyltransferase regulatory axis in cancer
BioProject PRJNA177817

Download family Format
SOFT formatted family file(s) SOFTHelp
MINiML formatted family file(s) MINiMLHelp
Series Matrix File(s) TXTHelp

Supplementary file Size Download File type/resource
GSE41651_RAW.tar 92.6 Mb (http)(custom) TAR (of TXT)
Processed data included within Sample table
Processed data provided as supplementary file

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