|
| Status |
Public on Aug 01, 2013 |
| Title |
Combinatorial treatment of DNMT inhibitor and LSD1 inhibitor results in cell growth inhibition and reexpression of epigenetically silenced genes (methylation) |
| Organism |
Homo sapiens |
| Experiment type |
Methylation profiling by array
|
| Summary |
A combinatorial treatment consisting of a DNMTi and a LSD1i shows synergistic effects in reactivating aberrantly silenced genes by enriching H3K4me2 and H3K4me.
|
| |
|
| Overall design |
Bisulphite converted DNA from the 8 samples were hybridised to the Illumina Infinium HM450 Human Methylation Beadchip
|
| |
|
| Contributor(s) |
Han H, Yang X |
| Citation(s) |
24040395 |
| Submission date |
Oct 11, 2012 |
| Last update date |
Mar 22, 2019 |
| Contact name |
Xiaojing Yang |
| E-mail(s) |
xiaojiny@usc.edu
|
| Phone |
(323)865-0740
|
| Organization name |
USC/Norris Comprehensive Cancer Center
|
| Street address |
1441 Eastlake Ave, Room 7336
|
| City |
Los Angeles |
| State/province |
CA |
| ZIP/Postal code |
90033 |
| Country |
USA |
| |
|
| Platforms (1) |
| GPL13534 |
Illumina HumanMethylation450 BeadChip (HumanMethylation450_15017482) |
|
| Samples (8)
|
|
| This SubSeries is part of SuperSeries: |
| GSE41754 |
Combinatorial treatment of DNMT inhibitor and LSD1 inhibitor results in cell growth inhibition and reexpression of epigenetically silenced genes |
|
| Relations |
| BioProject |
PRJNA177920 |
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