|
| Status |
Public on Jan 29, 2006 |
| Title |
Effect of ionizing radiation on procoagulant activity |
| Organism |
Homo sapiens |
| Experiment type |
Expression profiling by array
|
| Summary |
Ionizing radiation (IR) is associated with thrombotic vascular occlusion. Thrombosis in malignancy predicts a poor clinical outcome. Tissue factor (TF) is the initiator of the extrinsic co-agulation system and induces thrombus formation. Our study examined whether IR induced TF expression and procoagulability in the myelomonocytic leukemia THP-1 cell model. We further investigated coordinated gene alterations associated with TF upregulation and IR-induced thrombogenicity. Gene expression profiling revealed IR to increase the expression of inflammatory and apoptosis-related pathways, contributing to TF upregulation and increased TF procoagulability on day 7 post IR. The upregulation of these pathways together with TF upregulation contributed to the increased thrombogenic potential of tissues post application of IR.
Keywords: irridiation response
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| Overall design |
THP-1 cells were harvested on day 3 (1 sample) and day 7 (3 samples) post irradiation. For each time point untreated control samples were run.
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| Contributor(s) |
Goldin-Lang P, Wittchen F, Witt H |
| Citation(s) |
17640852 |
| Submission date |
Jan 27, 2006 |
| Last update date |
Mar 25, 2019 |
| Contact name |
Henning Witt |
| E-mail(s) |
witt@molgen.mpg.de
|
| Phone |
++49-30-450578727
|
| Organization name |
Max Planck Institute for Molecular Genetics
|
| Department |
Hans Lehrach
|
| Lab |
Patricia Ruiz
|
| Street address |
Ihnestrasse 65
|
| City |
Berlin |
| ZIP/Postal code |
14195 |
| Country |
Germany |
| |
|
| Platforms (1) |
| GPL570 |
[HG-U133_Plus_2] Affymetrix Human Genome U133 Plus 2.0 Array |
|
| Samples (8)
|
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| Relations |
| BioProject |
PRJNA94931 |
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