|
| Status |
Public on Aug 26, 2013 |
| Title |
A long noncoding RNA mediates both activation and repression of immune response genes. |
| Organism |
Mus musculus |
| Experiment type |
Expression profiling by high throughput sequencing
|
| Summary |
An inducible program of inflammatory gene expression is central to antimicrobial defenses. This response is controlled by a collaboration involving signal-dependent activation of transcription factors, transcriptional co-regulators, and chromatin-modifying factors. We have identified a long noncoding RNA (lncRNA) that acts as a key regulator of this inflammatory response. Pattern recognition receptors such as the Toll-like receptors induce the expression of numerous lncRNAs. One of these, lincRNA-Cox2, mediates both the activation and repression of distinct classes of immune genes. Transcriptional repression of target genes is dependent on interactions of lincRNA-Cox2 with heterogeneous nuclear ribonucleoprotein A/B and A2/B1. Collectively, these studies unveil a central role of lincRNA-Cox2 as a broad-acting regulatory component of the circuit that controls the inflammatory response
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| |
|
| Overall design |
Examination of Mus musculus (C57BL/6 background) gene expression changes following stimulation with Pam3Cys4 in presence or absence of shRNA specifically targetting lncRNA-COX2
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| |
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| Contributor(s) |
Carpenter S, Fitzgerald KA, Caffrey DR, Aiello D |
| Citation(s) |
23907535 |
| Submission date |
Sep 19, 2012 |
| Last update date |
May 15, 2019 |
| Contact name |
Daniel Aiello |
| E-mail(s) |
daiello1@yahoo.com
|
| Phone |
5083205538
|
| Organization name |
UMASS Medical School
|
| Department |
Division of Infectious Diseases and Immunology, Department of Medicine
|
| Lab |
Caffrey
|
| Street address |
364 plantation Street
|
| City |
Worcester |
| State/province |
ma |
| ZIP/Postal code |
01605 |
| Country |
USA |
| |
|
| Platforms (1) |
| GPL13112 |
Illumina HiSeq 2000 (Mus musculus) |
|
| Samples (4)
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|
| Relations |
| BioProject |
PRJNA175479 |
| SRA |
SRP015811 |
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