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Series GSE40978 Query DataSets for GSE40978
Status Public on Aug 26, 2013
Title A long noncoding RNA mediates both activation and repression of immune response genes.
Organism Mus musculus
Experiment type Expression profiling by high throughput sequencing
Summary An inducible program of inflammatory gene expression is central to antimicrobial defenses. This response is controlled by a collaboration involving signal-dependent activation of transcription factors, transcriptional co-regulators, and chromatin-modifying factors. We have identified a long noncoding RNA (lncRNA) that acts as a key regulator of this inflammatory response. Pattern recognition receptors such as the Toll-like receptors induce the expression of numerous lncRNAs. One of these, lincRNA-Cox2, mediates both the activation and repression of distinct classes of immune genes. Transcriptional repression of target genes is dependent on interactions of lincRNA-Cox2 with heterogeneous nuclear ribonucleoprotein A/B and A2/B1. Collectively, these studies unveil a central role of lincRNA-Cox2 as a broad-acting regulatory component of the circuit that controls the inflammatory response
Overall design Examination of Mus musculus (C57BL/6 background) gene expression changes following stimulation with Pam3Cys4 in presence or absence of shRNA specifically targetting lncRNA-COX2
Contributor(s) Carpenter S, Fitzgerald KA, Caffrey DR, Aiello D
Citation(s) 23907535
Submission date Sep 19, 2012
Last update date May 15, 2019
Contact name Daniel Aiello
Phone 5083205538
Organization name UMASS Medical School
Department Division of Infectious Diseases and Immunology, Department of Medicine
Lab Caffrey
Street address 364 plantation Street
City Worcester
State/province ma
ZIP/Postal code 01605
Country USA
Platforms (1)
GPL13112 Illumina HiSeq 2000 (Mus musculus)
Samples (4)
GSM1006301 Sample_EV_CTL
GSM1006302 Sample_EV_CTL_P3C4-5h
GSM1006303 Sample_LincRNA_CTL
BioProject PRJNA175479
SRA SRP015811

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Supplementary file Size Download File type/resource
GSE40978_RAW.tar 580.0 Kb (http)(custom) TAR (of TXT)
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Raw data are available in SRA
Processed data provided as supplementary file

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