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| Status |
Public on Dec 18, 2012 |
| Title |
Transient low-dose decitabine treatment of primary AML samples |
| Organism |
Homo sapiens |
| Experiment type |
Methylation profiling by genome tiling array
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| Summary |
Genome-wide DNA methylation profiling of primary AML samples treated with 100nM decitabine (DAC), cytarabine (AraC), or DMSO. Eight distinct AML samples were grown using an in vitro stromal co-culture system for 4 days and then treated with either DAC, Ara-C or DMSO for 3 days. DNA was prepared for genome-wide methylation analysis with the Illumina Infinium 450k Human DNA methylation BeadChip. DNA from each sample/treatment was analyzed on duplicate arrays.
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| Overall design |
Bisulfite-converted DNA from 24 samples was hybridised to the Illumina Infinium 450k Human Methylation Beadchip in duplicate (replicates are indicated by array plate number).
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| Contributor(s) |
Klco J, Spencer D |
| Citation(s) |
23297133 |
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| Submission date |
Sep 13, 2012 |
| Last update date |
Mar 22, 2019 |
| Contact name |
Nobish Varghese |
| E-mail(s) |
nvarghese@path.wustl.edu
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| Organization name |
Washington University in St.Louis
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| Street address |
4444 Forest Park Ave.
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| City |
StLouis |
| State/province |
MO |
| ZIP/Postal code |
63110 |
| Country |
USA |
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| Platforms (1) |
| GPL13534 |
Illumina HumanMethylation450 BeadChip (HumanMethylation450_15017482) |
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| Samples (48)
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| GSM1003835 |
UPN 410324, 3 day AraC treatment, array plate number 3 |
| GSM1003836 |
UPN 410324, 3 day AraC treatment, array plate number 7 |
| GSM1003837 |
UPN 410324, 3 day DAC treatment, array plate number 3 |
| GSM1003838 |
UPN 410324, 3 day DAC treatment, array plate number 7 |
| GSM1003839 |
UPN 410324, 3 day Mock treatment, array plate number 3 |
| GSM1003840 |
UPN 410324, 3 day Mock treatment, array plate number 7 |
| GSM1003841 |
UPN 632729, 3 day AraC treatment, array plate number 10 |
| GSM1003842 |
UPN 632729, 3 day AraC treatment, array plate number 9 |
| GSM1003843 |
UPN 632729, 3 day DAC treatment, array plate number 10 |
| GSM1003844 |
UPN 632729, 3 day DAC treatment, array plate number 9 |
| GSM1003845 |
UPN 632729, 3 day Mock treatment, array plate number 10 |
| GSM1003846 |
UPN 632729, 3 day Mock treatment, array plate number 9 |
| GSM1003847 |
UPN 721214, 3 day AraC treatment, array plate number 3 |
| GSM1003848 |
UPN 721214, 3 day AraC treatment, array plate number 7 |
| GSM1003849 |
UPN 721214, 3 day DAC treatment, array plate number 3 |
| GSM1003850 |
UPN 721214, 3 day DAC treatment, array plate number 7 |
| GSM1003851 |
UPN 721214, 3 day Mock treatment, array plate number 3 |
| GSM1003852 |
UPN 721214, 3 day Mock treatment, array plate number 7 |
| GSM1003853 |
UPN 737451, 3 day AraC treatment, array plate number 3 |
| GSM1003854 |
UPN 737451, 3 day AraC treatment, array plate number 7 |
| GSM1003855 |
UPN 737451, 3 day DAC treatment, array plate number 3 |
| GSM1003856 |
UPN 737451, 3 day DAC treatment, array plate number 7 |
| GSM1003857 |
UPN 737451, 3 day Mock treatment, array plate number 3 |
| GSM1003858 |
UPN 737451, 3 day Mock treatment, array plate number 7 |
| GSM1003859 |
UPN 775109, 3 day AraC treatment, array plate number 10 |
| GSM1003860 |
UPN 775109, 3 day AraC treatment, array plate number 9 |
| GSM1003861 |
UPN 775109, 3 day DAC treatment, array plate number 10 |
| GSM1003862 |
UPN 775109, 3 day DAC treatment, array plate number 9 |
| GSM1003863 |
UPN 775109, 3 day Mock treatment, array plate number 10 |
| GSM1003864 |
UPN 775109, 3 day Mock treatment, array plate number 9 |
| GSM1003865 |
UPN 831711, 3 day AraC treatment, array plate number 10 |
| GSM1003866 |
UPN 831711, 3 day AraC treatment, array plate number 9 |
| GSM1003867 |
UPN 831711, 3 day DAC treatment, array plate number 10 |
| GSM1003868 |
UPN 831711, 3 day DAC treatment, array plate number 9 |
| GSM1003869 |
UPN 831711, 3 day Mock treatment, array plate number 10 |
| GSM1003870 |
UPN 831711, 3 day Mock treatment, array plate number 9 |
| GSM1003871 |
UPN 869922, 3 day AraC treatment, array plate number 10 |
| GSM1003872 |
UPN 869922, 3 day AraC treatment, array plate number 9 |
| GSM1003873 |
UPN 869922, 3 day DAC treatment, array plate number 10 |
| GSM1003874 |
UPN 869922, 3 day DAC treatment, array plate number 9 |
| GSM1003875 |
UPN 869922, 3 day Mock treatment, array plate number 10 |
| GSM1003876 |
UPN 869922, 3 day Mock treatment, array plate number 9 |
| GSM1003877 |
UPN 989176, 3 day AraC treatment, array plate number 3 |
| GSM1003878 |
UPN 989176, 3 day AraC treatment, array plate number 7 |
| GSM1003879 |
UPN 989176, 3 day DAC treatment, array plate number 3 |
| GSM1003880 |
UPN 989176, 3 day DAC treatment, array plate number 7 |
| GSM1003881 |
UPN 989176, 3 day Mock treatment, array plate number 3 |
| GSM1003882 |
UPN 989176, 3 day Mock treatment, array plate number 7 |
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| This SubSeries is part of SuperSeries: |
| GSE40871 |
Gene expression and methylation profiling in primary AML cells treated with decitabine and cytarabine |
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| Relations |
| BioProject |
PRJNA175142 |
| Supplementary file |
Size |
Download |
File type/resource |
| GSE40870_RAW.tar |
183.1 Mb |
(http)(custom) |
TAR |
| GSE40870_unmethylated_methylated_signals.txt.gz |
271.5 Mb |
(ftp)(http) |
TXT |
| Processed data included within Sample table |
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