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Series GSE40384 Query DataSets for GSE40384
Status Public on Jul 20, 2013
Title siRNA Knockdown of SWI/SNF complex proteins in prostate cancer cell lines
Organism Homo sapiens
Experiment type Expression profiling by array
Summary Here we performed transcriptional profiling of the prostate cancer cell lines LNCaP and 22Rv1 comparing non-targeting siRNA treatment versus siRNAs targeting SWI/SNF complex proteins (SMARCA2, SMARCA4, and SMARCB1). Goal was to determine the effect of SWI/SNF knockdown on gene expression in prostate cancer.
Overall design Two-condition experiment: non-targeting siRNA versus SWI/SNF-siRNA treated cells. Three SWI/SNF proteins were targeted: SMARCA2, SMARCA4, and SMARB1. Biological replicates: 1 control replicate, 2 treatment replicates per SWI/SNF protein. Technical replicates: 1 replicate per SWI/SNF protein. Cell lines: 22Rv1 and LNCaP.
Contributor(s) Jing X, Iyer MK, Prensner JR
Citation(s) 24076601
Submission date Aug 27, 2012
Last update date Feb 22, 2018
Contact name Matthew Iyer
Phone 7346154503
Organization name University of Michigan
Department Michigan Center for Translational Pathology
Lab Chinnaiyan Lab
Street address 5316 CCGC 0940 1400 E. Medical Center Drive
City Ann Arbor
State/province MI
ZIP/Postal code 48109-0940
Country USA
Platforms (1)
GPL4133 Agilent-014850 Whole Human Genome Microarray 4x44K G4112F (Feature Number version)
Samples (12)
GSM992643 22RV1 SMARCB1 siRNA-1
GSM992644 22RV1 SMARCB1 siRNA-2
GSM992645 22RV1 SMARCA4 siRNA-1
This SubSeries is part of SuperSeries:
GSE40386 SChLAP-1, a long non-coding RNA, antagonizes the SWI/SNF complex and coordinates aggressive prostate cancer.
BioProject PRJNA173821

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Series Matrix File(s) TXTHelp

Supplementary file Size Download File type/resource
GSE40384_RAW.tar 178.1 Mb (http)(custom) TAR (of TXT)
Processed data included within Sample table

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