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Series GSE40206 Query DataSets for GSE40206
Status Public on Feb 10, 2016
Title Differential expression of genes and protein networks in the primary breast tumor that proceed to distant metastasis
Organism Homo sapiens
Experiment type Expression profiling by array
Summary The presence or absence of lymph node metastasis plays a major role in the prediction of prognosis and subsequent patient management. However, good proportion of patients who display lymph node positivity remain disease free for 3 years or more, after the initial treatment, while a third of those who were lymph node negative at presentation, develop distant metastasis within the same period. We performed gene expression profiling on a cohort Indian breast cancer patients followed up for a period of 3-5 years and in comparison with a previously published Caucasian cohort data, we identified gene signatures that are associated with distant metastasis. This association was irrespective of the hormone receptor status. Our results show that the genes that signify immune system development and response are repressed, while factors for DNA replication are up regulated in patients who develop distant metastasis. A large number of genes encoding proteins involved in the mitotic spindle formation that belong to the TRIM28 protein network, are differentially regulated in the metastatic tumors. Also, there was a significant overlap of genes reported in a mouse model of bone metastasis, with patients who developed bone metastasis in our cohort. In conclusion, we present for the first time probable gene signatures that correlate with distant metastasis in breast cancer patients irrespective of nodal or hormone receptor status
Overall design 80 indian breast cancer patients(samples),comprising of 22ER+(estrogen receptor),and 55 ER-.PR(progesterone receptor) ,HER and NOD status are also given in corresponding sample title and array files
Contributor(s) Kondaiah P, Damineni S, KUMAR N
Citation(s) 28721365
Mohsin Bashir, Surekha Damineni, Geetashree Mukherjee and Paturu Kondaiah. Activin-A signaling promotes epithelial-mesenchymal transition, invasion, and metastatic growth of breast cancer. npj Breast Cancer (2015) 1, 15007, published online 12 August 2015;
Submission date Aug 17, 2012
Last update date Jun 25, 2019
Contact name Neeraj KUMAR
Organization name Indian Institute of Science Bangalore
Department MRDG
Lab Prof. P Kondaiah lab
Street address Indian Institute of Science Bangalore
City Bangalore
ZIP/Postal code 560 012
Country India
Platforms (1)
GPL4133 Agilent-014850 Whole Human Genome Microarray 4x44K G4112F (Feature Number version)
Samples (80)
GSM988277 45T_NOD-_ER-_PR-_HER-
GSM988278 67T_NOD+_ER-_PR-_HER-
GSM988279 147T_NOD-_ER-_PR-_HER-
BioProject PRJNA173465

Download family Format
SOFT formatted family file(s) SOFTHelp
MINiML formatted family file(s) MINiMLHelp
Series Matrix File(s) TXTHelp

Supplementary file Size Download File type/resource
GSE40206_RAW.tar 1.1 Gb (http)(custom) TAR (of TXT)
Processed data included within Sample table

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