NCBI Logo
GEO Logo
   NCBI > GEO > Accession DisplayHelp Not logged in | LoginHelp
GEO help: Mouse over screen elements for information.
          Go
Series GSE4013 Query DataSets for GSE4013
Status Public on Jan 11, 2006
Title Host response to smallpox
Organism Homo sapiens
Experiment type Expression profiling by array
Summary Smallpox has played an unparalleled role in human history and remains a significant potential threat to public health. Despite the historical significance of this disease, we know little about the underlying pathophysiology or the virulence mechanisms of the causative agent, variola virus. To improve our understanding of variola pathogenesis and variola-host interactions, we examined the molecular and cellular features of hemorrhagic smallpox in cynomolgus macaques. We used cDNA microarrays to analyze host gene expression patterns in sequential blood samples from each of 22 infected animals. Variola infection elicited striking and temporally coordinated patterns of gene expression in peripheral blood. Of particular interest were features that appear to represent an IFN response, cell proliferation, immunoglobulin gene expression, viral dose-dependent gene expression patterns, and viral modulation of the host immune response. The virtual absence of a tumor necrosis factor /NF-B-activated transcriptional program in the face of an overwhelming systemic infection suggests that variola gene products may ablate this response. These results provide a detailed picture of the host transcriptional response during smallpox infection, and may help guide the development of diagnostic, therapeutic, and prophylactic strategies.
Groups of assays that are related as part of a time series.
Keywords: time_series_design
 
Overall design Using regression correlation
 
Contributor(s) Rubins K
Citation(s) 15477590
Submission date Jan 10, 2006
Last update date Jul 29, 2013
Organization Stanford Microarray Database (SMD)
E-mail(s) array@genome.stanford.edu
Phone 650-498-6012
URL http://genome-www5.stanford.edu/
Department Stanford University, School of Medicine
Street address 300 Pasteur Drive
City Stanford
State/province CA
ZIP/Postal code 94305
Country USA
 
Platforms (3)
GPL3093 LC-25
GPL3346 LC-24
GPL3347 LC-26
Samples (167)
GSM91703 "099 Day35 in-vivo SP Inf, PBMC 1st TC, relabel"
GSM91704 "099 Day42 in-vivo SP Inf, PBMC 1st TC, relabel"
GSM91705 "437 Day4 in-vivo SP Inf, PBMC 2nd TC, relabel"
Relations
BioProject PRJNA95109

Download family Format
SOFT formatted family file(s) SOFTHelp
MINiML formatted family file(s) MINiMLHelp
Series Matrix File(s) TXTHelp

Supplementary data files not provided
| NLM | NIH | GEO Help | Disclaimer | Accessibility |
NCBI Home NCBI Search NCBI SiteMap