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Series GSE40086 Query DataSets for GSE40086
Status Public on Sep 16, 2012
Title A transcription factor based mechanism for mouse heterochromatin formation
Organism Mus musculus
Experiment type Genome binding/occupancy profiling by high throughput sequencing
Summary We identify Pax3 and Pax9 transcription factors (TFs) as important regulators of mouse heterochromatin. Simultaneous depletion of these factors results in loss of H3K9me3 from Major Satellite repeats and dramatic transcript overexpression. H3K9me3 enrichment at intergenic major satellite repeats is only present if these sequences retain intact Pax and other TF binding sites.
Overall design H3K9me3 ChIP-seq in mouse ES cells wt and Pax3 KO and Pax3 KO/Pax9 KD
Contributor(s) De La Rosa-Velazquez IA, Karslioglu AB, Manke T, Diehl S, Jenuwein T
Citation(s) 22983563
Submission date Aug 13, 2012
Last update date May 15, 2019
Contact name Thomas Manke
Organization name Max-Planck-Institute for Immunobiology and Epigenetics
Department Bioinformatics and Deep-Sequencing Unit
Street address Stuebeweg 51
City Freiburg im Breisgau
ZIP/Postal code 79108
Country Germany
Platforms (1)
GPL11002 Illumina Genome Analyzer IIx (Mus musculus)
Samples (6)
GSM984793 M1-1 H3K9me3 #1926
GSM984794 M1-3 H3K9me3 #1926
GSM984795 M1-3/9 H3K9me3 #1926
BioProject PRJNA172759
SRA SRP014827

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SOFT formatted family file(s) SOFTHelp
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Series Matrix File(s) TXTHelp

Supplementary file Size Download File type/resource 677.1 Mb (ftp)(http) BW 841.8 Mb (ftp)(http) BW 837.7 Mb (ftp)(http) BW 689.7 Mb (ftp)(http) BW 870.1 Mb (ftp)(http) BW 869.2 Mb (ftp)(http) BW
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