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Series GSE39962 Query DataSets for GSE39962
Status Public on Jul 05, 2013
Title Distinct signal transduction pathways downstream of the (P)RR revealed by microarray and ChIP-chip analyses [Expt: Geni_Bafi]
Organism Homo sapiens
Experiment type Expression profiling by array
Summary Within the overall project, we performed a set of microarray and chromatin-immunoprecipitation (ChIP)-chip experiments using siRNA against the (pro)renin receptor ((P)RR), stable overexpression of PLZF, the PLZF translocation inhibitor genistein and the specific V-ATPase inhibitor bafilomycin to dissect transcriptional pathways downstream of the (P)RR.
Overall design In this dataset, we include the expression data obtained from KELLY cells incubated with genistein or bafilomycin A1. Five intervention samples and three control samples were analyzed. We generated the following pairwise comparisons using Chipinspector (Genomatix Software GmbH) and a FDR of 0.5% (bafilomycin), 5% (genistein): genistein- versus DMSO- and bafilomycin- versus DMSO-treated cells.
ChipInspector carries out significance analysis on the single probe level. Normalized probe set level data not provided for individual Sample records. Processed data is available on Series record.
Contributor(s) Funke-Kaiser H, Zaade D
Citation(s) 23469216
Submission date Aug 08, 2012
Last update date Jan 25, 2019
Contact name Daniela Zaade
Phone 0049(0)30450525304
Organization name Charité
Department Center for Cardiovascular Research
Lab AG Heiko Funke-Kaiser
Street address Hessische Straße 3-4
City Berlin
ZIP/Postal code 10115
Country Germany
Platforms (1)
GPL10739 [HuGene-1_0-st] Affymetrix Human Gene 1.0 ST Array [probe set (exon) version]
Samples (8)
GSM982320 KELLY, genistein incubation, rep 1
GSM982321 KELLY, genistein incubation, rep 3
GSM982322 KELLY, bafilomycin incubation, rep 1
This SubSeries is part of SuperSeries:
GSE39965 Distinct signal transduction pathways downstream of the (P)RR revealed by microarray and ChIP-chip analyses
BioProject PRJNA172170

Download family Format
SOFT formatted family file(s) SOFTHelp
MINiML formatted family file(s) MINiMLHelp
Series Matrix File(s) TXTHelp

Supplementary file Size Download File type/resource
GSE39962_FK_71-73_vs_77-78-79.txt.gz 6.4 Kb (ftp)(http) TXT
GSE39962_FK_74-75-76_vs_77-78-79.txt.gz 18.4 Kb (ftp)(http) TXT
GSE39962_RAW.tar 34.3 Mb (http)(custom) TAR (of CEL)
Processed data are available on Series record

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