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Series GSE39637 Query DataSets for GSE39637
Status Public on Mar 18, 2013
Title Gene expression in pluripotent and TSKM-iPS induction cells.
Organism Mus musculus
Experiment type Expression profiling by array
Summary We found that Tet1 (T) can substitute Oct4 and initiates somatic cell reprogramming in combination with Sox2 (S), Klf4 (K) and c-Myc (M). Moreover, the TSKM secondary reprogramming can proceed rapidly with widespread accompanying increase of 5hmC and 5mC at TSS and ES-active regulation regions followed by 5mC-5hmC pattern switchand, and the activation of endogenous Oct4 and Nanog was Tet1 and 5hmC involved in this process.
We used microarray to explore the global expression change during the reprogramming process
Overall design Examination of gene expression change in 3 different cell lines covering the main stages during the reprogramming process
Contributor(s) Gao Y, Chen J, Cai T, Gao S
Citation(s) 23499384
Submission date Jul 25, 2012
Last update date Mar 04, 2019
Contact name Tao Cai
Organization name National Institute Of Biological Sciences, Beijing (NIBS)
Lab Sequencing Facility
Street address No. 7 Science Park Road, Zhongguancun Life Science Park
City Beijing
ZIP/Postal code 102206
Country China
Platforms (1)
GPL6246 [MoGene-1_0-st] Affymetrix Mouse Gene 1.0 ST Array [transcript (gene) version]
Samples (9)
GSM973518 fibroblast cell line rep1
GSM973519 fibroblast cell line rep2
GSM973520 fibroblast cell line rep3
This SubSeries is part of SuperSeries:
GSE39639 Gene expression and 5hmC/5mC state in pluripotent and TSKM-iPS induction cells
BioProject PRJNA171322

Download family Format
SOFT formatted family file(s) SOFTHelp
MINiML formatted family file(s) MINiMLHelp
Series Matrix File(s) TXTHelp

Supplementary file Size Download File type/resource
GSE39637_RAW.tar 36.5 Mb (http)(custom) TAR (of CEL)
Processed data included within Sample table

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