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Series GSE39509 Query DataSets for GSE39509
Status Public on Jan 14, 2013
Title Lineage analysis of basal epithelial cells reveals their unexpected plasticity and supports a cell of origin model for prostate cancer heterogeneity
Organism Mus musculus
Experiment type Expression profiling by high throughput sequencing
Summary We used RNA-seq to compare the expression profiles of mouse prostate tumors originated from epithelial basal cells to those originated from luminal cells. We next generated expression signatures for both basal and luminal origin tumors by comparison of tumor samples to their respective controls. By comparing luminal to basal signatures we identified a prognostic molecular signature for prostate cancer patient survival.
Overall design Pten was deleted in prostate basal or luminal cells to induce tumor formation and tumor expression profiles were analyzed by RNA-seq.
Contributor(s) Wang ZA, Mitrofanova A, Bergren SK, Abate-Shen C, Cardiff RD, Califano A, Shen MM
Citation(s) 23434823
Submission date Jul 19, 2012
Last update date May 15, 2019
Contact name Antonina Mitrofanova
Organization name Rutgers University
Street address 65 Bergen Street, Rm 923B
City Newark
State/province NJ
ZIP/Postal code 07107
Country USA
Platforms (1)
GPL13112 Illumina HiSeq 2000 (Mus musculus)
Samples (34)
GSM970463 basal control 1
GSM970464 basal control 2
GSM970465 basal control 3
BioProject PRJNA171061
SRA SRP015136

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Supplementary file Size Download File type/resource
GSE39509_RNAseq_mouse_expression.txt.gz 2.7 Mb (ftp)(http) TXT
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