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| Status |
Public on Feb 13, 2013 |
| Title |
Modulation of gene expression by ZNF143, THAP11 and NOTCH1 via overlapping binding sites in mammalian cells |
| Organisms |
Homo sapiens; Mus musculus |
| Experiment type |
Expression profiling by high throughput sequencing
Genome binding/occupancy profiling by high throughput sequencing
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| Summary |
In this study we investigated the genome wide DNA binding profile of ZNF143 and ICN1 in human and murine cells. We also analyzed the expression profile in human cells after overexpression or knockdown of ZNF143.
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| Overall design |
To identify ZNF143 targets we performed ChIP-seq on 4 human cells lines and 3 murine cell types. We also identified, by ChIP-seq, ICN1 binding sites in HPB-ALL cells. To identify directly regulated genes by ZNF143, we analyzed, by RNA-seq, the expression profile after knockdown and overexpression of the transcription factor.
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| Contributor(s) |
NGONDO-MBONGO RP, MYSLINSKI E, CARBON P |
| Citation(s) |
23408857 |
| Submission date |
Jul 11, 2012 |
| Last update date |
May 15, 2019 |
| Contact name |
PHILIPPE CARBON |
| Organization name |
IBMC
|
| Department |
UPR9002 ARN du CNRS
|
| Street address |
15 rue René Descartes
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| City |
Strasbourg |
| ZIP/Postal code |
67084 |
| Country |
France |
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| Platforms (3) |
| GPL10999 |
Illumina Genome Analyzer IIx (Homo sapiens) |
| GPL11002 |
Illumina Genome Analyzer IIx (Mus musculus) |
| GPL11154 |
Illumina HiSeq 2000 (Homo sapiens) |
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| Samples (17)
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| Relations |
| BioProject |
PRJNA170436 |
| SRA |
SRP014190 |
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