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Series GSE39102 Query DataSets for GSE39102
Status Public on Dec 10, 2012
Title CXCL12 and IGF1 select for cancer cell populations with enhanced bone metastasis ability
Organism Homo sapiens
Experiment type Expression profiling by array
Summary CXCL12 and IGF1 confer on cancer cells survival advantage. Src potentiates cancer cells' reponse to CXCL12 and IGF1 by strengthening AKT activation. Long-term incubation of CXCL12 and IGF1 select for cancer cells with enhanced Src activity and bone metastasis potential.
Overall design MDA-MB-231 cells were incubated for three weeks in growth medium of reduced serum concentration (0.2%) with or without CXCL12 (30 ng/ml) and IGF1 (10 ng/ml). Cell populations survive under these condidtions are expanded by regular growth medium with 10% serum. Two biological replicates were profiled for each condition.
Contributor(s) Zhang XH, Jin X, Massague J
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Submission date Jul 04, 2012
Last update date Dec 06, 2018
Contact name Xiang Zhang
Organization name Baylor College of Medicine
Department Lester and Sue Smith Breast Center
Lab Zhang
Street address One Baylor Plaza, BCM600
City Houston
State/province TX
ZIP/Postal code 77030
Country USA
Platforms (1)
GPL571 [HG-U133A_2] Affymetrix Human Genome U133A 2.0 Array
Samples (4)
GSM956157 MDA-MB-231-0-0 A
GSM956158 MDA-MB-231-0-0 B
GSM956159 MDA-MB-231-10-30 A
BioProject PRJNA170054

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SOFT formatted family file(s) SOFTHelp
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Series Matrix File(s) TXTHelp

Supplementary file Size Download File type/resource
GSE39102_RAW.tar 7.3 Mb (http)(custom) TAR (of CEL)
Processed data included within Sample table

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