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Series GSE38690 Query DataSets for GSE38690
Status Public on Jun 06, 2013
Title The ERRalpha metabolic nuclear receptor controls growth of colon cancer cells
Organism Homo sapiens
Experiment type Expression profiling by array
Summary Estrogen-Related Receptor alpha (ERRα) is a nuclear receptor that acts principally as a regulator of metabolism processes particularly in tissues subjected to high-energy demand. Besides its implication in energy metabolism and mitochondrial biogenesis, ERRα was recently associated with tumorigenesis. Notably, increased expression of ERRα was noted in different cancerous tissues as breast, ovary and colon. However, supplemental studies are required to better understand the role of ERRα in colon carcinoma.
We used microarrays to detail gene expression during ERRalpha knockdown in HCT116 cells and identified distinct classes of up and down-regulated genes.
 
Overall design Triplicate of HCT116 cell line was infected witn shscrambled(shCTL) and shERRalpha lentivirus and used for RNA extraction and hybridization on Affymetrix microarrays.
 
Contributor(s) Bernatchez G, Giroux V, Lassalle T, Carpentier A, Rivard N, Carrier JC
Citation(s) 23720198
Submission date Jun 13, 2012
Last update date Jan 25, 2019
Contact name Julie Carrier
E-mail(s) julie.carrier2@usherbrooke.ca
Organization name Université de Sherbrooke
Department Médecine(Gastroentérologie)
Street address 3001, 12ième avenue nord
City Sherbrooke
State/province Québec
ZIP/Postal code J1H 5N4
Country Canada
 
Platforms (1)
GPL10739 [HuGene-1_0-st] Affymetrix Human Gene 1.0 ST Array [probe set (exon) version]
Samples (6)
GSM947590 HCT116 shscrambled, biological rep1
GSM947591 HCT116 shscrambled, biological rep2
GSM947592 HCT116 shscrambled, biological rep3
Relations
BioProject PRJNA168442

Download family Format
SOFT formatted family file(s) SOFTHelp
MINiML formatted family file(s) MINiMLHelp
Series Matrix File(s) TXTHelp

Supplementary file Size Download File type/resource
GSE38690_RAW.tar 20.5 Mb (http)(custom) TAR (of CEL)
GSE38690_t-test.txt.gz 41.3 Kb (ftp)(http) TXT
Processed data included within Sample table

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