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Series GSE37965 Query DataSets for GSE37965
Status Public on Oct 17, 2012
Title DNA methylation profiling in breast cancer discordant identical twins
Organism Homo sapiens
Experiment type Methylation profiling by genome tiling array
Summary We obtained a comprehensive DNA methylation profile of 15 breast cancer discordant twins, using the high resolution Infinium HumanMethylation450 BeadChip platform (450K, Illumina), previously established to reliably detect methylation changes of more than 450,000 CpG sites. To provide insight into the temporal and causal relationships and predictive potential, samples from breast cancer patients before (7) and after diagnosis (8) were also analyzed. Using whole blood from 15 twin pairs discordant for breast cancer and high-resolution (450k) DNA methylation analysis we identified 403 differentially methylated CpG sites including known and novel potential breast cancer genes.
Overall design 30 Samples
Contributor(s) Heyn HA, Esteller M
Citation(s) 23054610
Submission date May 14, 2012
Last update date Mar 22, 2019
Contact name Manel Esteller
Organization name IDIBELL
Department PEBC
Lab Cancer Epigenetics
Street address Hospital Duran i Reynals Av. Gran Via s/n km, 2.7
City L'Hospitalet de Llobregat
State/province Barcelona
ZIP/Postal code 08908
Country Spain
Platforms (1)
GPL13534 Illumina HumanMethylation450 BeadChip (HumanMethylation450_15017482)
Samples (30)
GSM931079 Twin_Pair_1_healthy
GSM931080 Twin_Pair_2_healthy
GSM931081 Twin_Pair_3_affected
BioProject PRJNA165843

Download family Format
SOFT formatted family file(s) SOFTHelp
MINiML formatted family file(s) MINiMLHelp
Series Matrix File(s) TXTHelp

Supplementary file Size Download File type/resource
GSE37965_RAW.tar 183.1 Mb (http)(custom) TAR
Processed data included within Sample table

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