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Series GSE37757 Query DataSets for GSE37757
Status Public on Jul 01, 2012
Title Unraveling cell type–specific and reprogrammable human replication origin signatures associated with G-quadruplex consensus motifs
Organism Homo sapiens
Experiment type Genome binding/occupancy profiling by high throughput sequencing
Summary Short nascent strands purification coupled to next-generation sequencing allowed us to identify replication origins on human genome in an extensive way, by mapping replication origins in 4 different cell types, IMR-90 fibroblasts, hESC H9 cells, iPSC Th Cl-4 cells and HeLa cells.
We demonstrated the existence of a cell type-specific reprogrammable signature of the cell identity revealed by specific efficiencies of conserved origin positions and not by the selection of cell-type specific subsets of origins.
Overall design 4 different cell types were analyzed. For each cell types, 2 different biological replicates of short nascent strands at replication origins were purified. Each SNS sample was sequencing at least one time.
Contributor(s) Besnard E, Babled A, Lapasset L, Milhavet O, Parrinello H, Dantec C, Marin J, Lemaitre J
Citation(s) 22751019
Submission date May 04, 2012
Last update date May 15, 2019
Contact name Emilie Besnard
Organization name Institute of Functional Genomics
Lab Genome Plasticity and Aging
Street address 141 rue de la Cardonille
ZIP/Postal code 34000
Country France
Platforms (1)
GPL9115 Illumina Genome Analyzer II (Homo sapiens)
Samples (4)
GSM927235 IMR-90
GSM927236 hESC H9
GSM927237 iPSC Thomson clone 4
BioProject PRJNA163241
SRA SRP012667

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Supplementary file Size Download File type/resource
GSE37757_RAW.tar 9.4 Gb (http)(custom) TAR (of BED)
SRA Run SelectorHelp
Raw data are available in SRA
Processed data provided as supplementary file

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